Autotaxin impedes anti-tumor immunity by suppressing chemotaxis and tumor infiltration of CD8+ T cells
E. Matas-Rico, E. Frijlink, I. van der Haar Avila, A. Menegakis, M. van Zon, A. J. Morris, J. Koster, F. Salgado-Polo, S. de Kivit, T. Lanca, A. Mazzocca, Z. Johnson, J. Haanen, T. N. Schumacher, A. Perrakis, , W. H. Moolenaar
This study shows that ATX secreted by melanoma cells repels CD8+ T cells, reducing their infiltration into tumors and impairing anti-tumor immunity.
bioRxiv · Feb 26, 2020Cancer Biology