W. H. Moolenaar

This study shows that ATX inhibitors targeting the ATX tunnel selectively block LPA signaling via P2Y receptors, with implications for pulmonary fibrosis treatment.

This study shows that ATX secreted by melanoma cells repels CD8+ T cells, reducing their infiltration into tumors and impairing anti-tumor immunity.

This study identifies RhoA-mDia2 signaling and Profilin-1 binding as regulators of CLIC4 translocation, which modulates filopodia length through actin dynamics.

This study identifies GDE3 as a GPI-specific phospholipase C that cleaves uPAR, reducing its proteolytic and non-proteolytic activities and altering cell behavior in breast cancer.