Author

A. Menny

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biophysics· 4

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Assay:cryo-EM· 2 Approach:microscopy & imaging analysis· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Assay:electrophysiology· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

D. Bubeck· 3 shared A. J. R. Heck· 1 shared A. L. B. Pyne· 1 shared A. P. Joseph· 1 shared A. P. Nievergelt· 1 shared A. R. Yon· 1 shared A. Rowley· 1 shared A. Taly· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiophysics

D. Bubeck

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Structural basis for how sMAC is packaged for clearance

A. Menny, M. V. Lukassen, E. C. Couves, V. Franc, A. J. R. Heck, D. Bubeck

The paper determines the structure of soluble membrane attack complex (sMAC) using cryoEM and XL-MS, revealing how clusterin inhibits its polymerization and how C9 is trapped in an intermediate conformation.

bioRxiv · Apr 6, 2021 · PreprintBiophysics

Mutational analysis to explore long-range allosteric coupling and decoupling in a pentameric channel receptor

S. N. Lefebvre, A. Taly, A. Menny, K. Medjebeur, P.-J. Corringer

The paper investigates long-range allosteric coupling and decoupling in a pentameric channel receptor using mutations, electrophysiology, fluorescence, and simulations.

bioRxiv · Jul 3, 2020Biophysics

Single-molecule kinetics of pore assembly by the membrane attack complex

E. S. Parsons, G. J. Stanley, A. L. B. Pyne, A. W. Hodel, A. P. Nievergelt, A. Menny, A. R. Yon, A. Rowley, R. P. Richter, G. E. Fantner, D. Bubeck, B. W. Hoogenboom

This study uses AFM to analyze MAC assembly kinetics, finding that C9 incorporation is the rate-limiting step in pore formation.

bioRxiv · Nov 16, 2018Biophysics

CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers

A. Menny, M. Serna, C. M. Boyd, S. Gardner, A. P. Joseph, B. P. Morgan, M. Topf, N. J. Brooks, D. Bubeck

This study uses cryo-EM to show how the complement membrane attack complex interacts with lipid bilayers through distinct mechanisms involving C6/C7 and C8/C9, revealing structural insights into pore formation and membrane disruption.

bioRxiv · Aug 17, 2018Biophysics