D. Bubeck

An oomycete effector co-opts a host RabGAP protein to remodel pathogen interface and subvert defense-related secretion

Structural basis for membrane attack complex inhibition by CD59

This study reveals how CD59 inhibits MAC pore formation by binding C8 and deflecting C9, using cryo-EM structures and simulations.

Structural insights into the assembly and activation of IL-27 signalling complex

This study determines the structure of the IL-27 receptor recognition complex using cryoEM, revealing how IL-27 bridges IL-27R and GP130 to initiate signaling.

Structural basis for how sMAC is packaged for clearance

The paper determines the structure of soluble membrane attack complex (sMAC) using cryoEM and XL-MS, revealing how clusterin inhibits its polymerization and how C9 is trapped in an intermediate conformation.

Structural basis for tuning activity and membrane specificity of bacterial cytolysins

This study investigates how bacterial cytolysins use cholesterol to selectively lyse cells by analyzing structural changes in intermedilysin bound to CD59.

Single-molecule kinetics of pore assembly by the membrane attack complex

This study uses AFM to analyze MAC assembly kinetics, finding that C9 incorporation is the rate-limiting step in pore formation.

CryoEM reveals how the complement membrane attack complex ruptures lipid bilayers

This study uses cryo-EM to show how the complement membrane attack complex interacts with lipid bilayers through distinct mechanisms involving C6/C7 and C8/C9, revealing structural insights into pore formation and membrane disruption.