Author

A. Miles

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 6

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Assay:whole-genome sequencing· 4 Research Focus:chromatin & epigenetic regulation· 3 Organism:human· 3 Organism:Drosophila· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

C. S. Clarkson· 5 shared D. Weetman· 4 shared M. J. Donnelly· 4 shared E. R. Lucas· 3 shared N. J. Harding· 2 shared The Anopheles gambiae 1000 Genomes Consortium· 2 shared A. A. Medjigbodo· 1 shared A. Asidi· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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5 shared papersEvolutionary Biology

C. S. Clarkson

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6 papers

Recent·Most cited

Cryptic population structure and insecticide resistance in Anopheles gambiae from the southern Democratic Republic of Congo

T. P. W. Dennis, P. Pescod, S. Barasa, L. T. Cerdeira, E. R. Lucas, C. S. Clarkson, A. Miles, A. Asidi, E. Z. Manzambi, E. Metelo, J. Zanga, S. N. Salambi, S. R. Irish, M. J. Donnelly, D. Weetman, F. W. Tezzo

The paper investigates insecticide resistance and population structure in Anopheles gambiae from southern DRC, finding high resistance and genetic differentiation between populations.

bioRxiv · Mar 12, 2024 · PreprintEvolutionary Biology

Parallel evolution in mosquito vectors - a duplicated esterase locus is associated with resistance to pirimiphos-methyl in An. gambiae

S. C. Nagi, E. R. Lucas, A. Egyir-Yawson, J. Essandoh, S. Dadzie, J. Chabi, L. S. Djogbenou, A. A. Medjigbodo, C. V. Edi, G. Ketoh, B. G. Koudou, F. Ashraf, C. S. Clarkson, A. Miles, D. Weetman, M. J. Donnelly

This study identifies a duplicated esterase locus associated with pirimiphos-methyl resistance in Anopheles gambiae through population genomic analysis.

bioRxiv · Feb 1, 2024 · PreprintEvolutionary Biology

Whole-genome sequencing of major malaria vectors reveals the evolution of new insecticide resistance variants in a longitudinal study in Burkina Faso

M. Kientega, C. S. Clarkson, N. Traore, T.-Y. J. Hui, S. M. O'Loughlin, A.-A. Millogo, F. A. Yao, P. S. Epopa, A. M. G. Belem, B. H. Jon, A. Miles, A. Burt, A. Diabate

The paper uses whole-genome sequencing of malaria vectors to track the emergence and spread of new insecticide resistance variants over time in Burkina Faso.

bioRxiv · Nov 20, 2023 · PreprintEvolutionary Biology

Mitochondrial variation in Anopheles gambiae and An. coluzzii: phylogeographic legacy of species isolation and mito-nuclear associations with metabolic resistance to pathogens and insecticides

J. E. Amaya Romero, C. Chenal, Y. Ben Chehida, A. Miles, C. S. Clarkson, V. Pedergnana, B. Wertheim, M. C. Fontaine

The paper analyzes mitochondrial DNA variation in Anopheles gambiae and An. coluzzii, revealing phylogeographic patterns and mito-nuclear associations with metabolic resistance.

bioRxiv · Jul 18, 2023 · PreprintEvolutionary Biology

Evolution of the insecticide target Rdl in African Anopheles is driven by interspecific andinterkaryotypic introgression

X. Grau-Bove, S. Tomlinson, A. O. O'Reilly, N. J. Harding, A. Miles, D. Kwiatkowski, M. J. Donnelly, D. Weetman, The Anopheles gambiae 1000 Genomes Consortium

The paper examines the evolution of insecticide resistance in Anopheles mosquitoes, showing how Rdl mutations spread through selective sweeps and introgression across species and karyotypes.

bioRxiv · Dec 17, 2019Evolutionary Biology

Whole genome sequencing reveals high complexity of copy number variation at insecticide resistance loci in malaria mosquitoes

E. R. Lucas, A. Miles, N. J. Harding, C. S. Clarkson, M. K. N. Lawniczak, D. P. Kwiatkowski, D. Weetman, M. J. Donnelly, The Anopheles gambiae 1000 Genomes Consortium

The paper uses whole-genome sequencing to identify copy number variations (CNVs) in Anopheles gambiae linked to insecticide resistance, finding CNVs enriched for resistance-related genes and under positive selection.

bioRxiv · Aug 25, 2018Evolutionary Biology