Akr1d1-/- mice have a sexually dimorphic metabolic phenotype with reduced fat mass, increased insulin sensitivity and hypertriglyceridemia in males
L. L. Gathercole, N. Nikolaou, A. Arvaniti, S. E. Harris, T. M. Poolman, J. M. Hazlehurst, D. V. Kratschmar, M. Todorcevic, A. Moolla, N. Dempster, R. C. Pink, M. F. Saikali, L. Bentley, T. M. Penning, C. Ohlsson, , J. W. Tomlinson
This study shows that AKR1D1 controls bile acid homeostasis and affects insulin sensitivity and lipid homeostasis in a sex-dependent manner in mice.
bioRxiv · Feb 2, 2021 · PreprintPhysiology