L. Bentley

A missense mutation in zinc finger homeobox-3 (ZFHX3) impedes growth and alters metabolism and hypothalamic gene expression in mice.

This study shows that a ZFHX3 mutation in mice reduces body weight, alters metabolism, and changes hypothalamic gene expression related to growth and energy balance.

A Wars2 mutant mouse shows a sex and diet specific change in fat distribution, reduced food intake and depot-specific upregulation of WAT browning

This study shows that Wars2V117L/V117L mice exhibit sex and diet-specific changes in fat distribution, reduced food intake, and depot-specific upregulation of WAT browning.

SARS-COV-2 Delta variant displays moderate resistance to neutralizing antibodies and spike protein properties of higher soluble ACE2 sensitivity, enhanced cleavage and fusogenic activity

This study evaluates the neutralization resistance and spike protein properties of SARS-CoV-2 B.1.617 variants, finding modest resistance to sera and therapeutic antibodies, but enhanced cleavage and fusogenic activity in Delta variants.

Key substitutions in the spike protein of SARS-CoV-2 variants can predict resistance to monoclonal antibodies, but other substitutions can modify the effects

The paper evaluates resistance of 25 therapeutic antibodies to SARS-CoV-2 variants with multiple spike substitutions, finding key substitutions predict resistance but other substitutions can modify it unpredictably.

Akr1d1-/- mice have a sexually dimorphic metabolic phenotype with reduced fat mass, increased insulin sensitivity and hypertriglyceridemia in males

This study shows that AKR1D1 controls bile acid homeostasis and affects insulin sensitivity and lipid homeostasis in a sex-dependent manner in mice.

Loss of Bardet-Biedl syndrome proteins causes synaptic aberrations in principal neurons

This study shows that loss of Bardet-Biedl syndrome proteins causes synaptic dysfunction in principal neurons, contributing to cognitive impairment in BBS patients.