Human macrophage polarization determines bacterial persistence of Staphylococcus aureus in a liver-on-chip-based infection model
F. Siwczak, Z. Cseresnyes, S. Carlstedt, A. Sigmund, M. Groeger, B. G. J. Surewaard, O. Werz, M. T. Figge, L. Tuchscherr, B. Loeffler, A. Mosig
This study shows that S. aureus targets liver macrophages in a liver-on-chip model, with M2 polarization promoting bacterial persistence and small colony variant formation.
bioRxiv · Nov 19, 2021Microbiology