Author

B. Loeffler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 1 Assay:metagenomics· 1 Assay:proteomics· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

M. T. Figge· 2 shared Z. Cseresnyes· 2 shared A. A. Brakhage· 1 shared A. Campos· 1 shared A. Carvalho· 1 shared A. Mosig· 1 shared A. Ramoji· 1 shared A. Sigmund· 1 shared

Activity by Year

2021-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCell Biology

M. T. Figge

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Re-direction of phagosomes to the recycling expulsion pathway by a fungal pathogen

L. Jia, M. Rafiq, L. Radosa, P. Hortschansky, C. A. Cunha, Z. Cseresnyes, T. Krueger, F. Schmidt, T. Heinekamp, M. Strassburger, B. Loeffler, T. Doenst, J. F. Lacerda, A. Campos, M. T. Figge, , A. A. Brakhage

This study identifies HscA as an effector protein from Aspergillus fumigatus that redirects phagosomes to the recycling expulsion pathway by anchoring p11, affecting susceptibility to invasive pulmonary aspergillosis.

bioRxiv · May 18, 2022Cell Biology

Human macrophage polarization determines bacterial persistence of Staphylococcus aureus in a liver-on-chip-based infection model

F. Siwczak, Z. Cseresnyes, S. Carlstedt, A. Sigmund, M. Groeger, B. G. J. Surewaard, O. Werz, M. T. Figge, L. Tuchscherr, B. Loeffler, A. Mosig

This study shows that S. aureus targets liver macrophages in a liver-on-chip model, with M2 polarization promoting bacterial persistence and small colony variant formation.

bioRxiv · Nov 19, 2021Microbiology

Gram-positive bacteria secrete RNA aptamers to activate human STING for IL-1β release.

S. N. Duduskar, M. Ghait, M. Westermann, H. Guo, A. Ramoji, C. Sponholz, B. Goehrig, T. Bruns, U. Neugebauer, J. Popp, L. P. N. Tuchscherr, B. Loeffler, N. Ueberschaar, C. Beemelmanns, M. Singer, , S. D. Deshmukh

This study identifies RNA aptamers secreted by Gram-positive bacteria that activate the STING pathway to induce IL-1β release in human macrophages.

bioRxiv · Jul 21, 2021 · PreprintImmunology

The local anaesthetic procaine prodrugs ProcCluster(R) and Procaine-hydrochloride impair SARS-CoV-2 replication in vitro

C. Häring, J. Schroeder, B. Loeffler, B. Engert, C. Ehrhardt

This study shows that procaine prodrugs inhibit SARS-CoV-2 and influenza A virus replication in vitro, suggesting potential for repurposing in antiviral therapy.

bioRxiv · Jun 7, 2021 · PreprintMicrobiology