O. Werz

Silybin A from Silybum marianum reprograms lipid metabolism to induce a cell fate-dependent class switch from triglycerides to phospholipids

This study identifies silybin A's role in reprogramming lipid metabolism to shift from triglycerides to phospholipids in liver cells, with implications for liver protection.

Lipid droplets control mitogenic lipid mediator production in human cancer cells

The paper shows lipid droplets regulate mitogenic lipid mediator production in cancer cells by controlling PUFAs availability through ATGL and DGAT1.

Human macrophage polarization determines bacterial persistence of Staphylococcus aureus in a liver-on-chip-based infection model

This study shows that S. aureus targets liver macrophages in a liver-on-chip model, with M2 polarization promoting bacterial persistence and small colony variant formation.

Mitochondrial fusion mediated by mitofusin 1 regulates macrophage mycobactericidal activity by enhancing autophagy

This study shows that MFN1-mediated mitochondrial fusion enhances ATP production, which supports autophagy and macrophage mycobactericidal activity against Mtb.

The Atlas of Inflammation-Resolution (AIR)

The AIR Atlas provides a web-based resource for exploring inflammation and resolution processes, enabling bioinformatics analyses and systems biology approaches through integrated molecular interaction maps.

Late life metformin treatment limits cell survival and shortens lifespan by triggering an aging-associated failure of energy metabolism.

This study shows that late-life metformin treatment reduces cell survival and lifespan by impairing energy metabolism, contrasting its beneficial effects in early life.