A targetable N-terminal motif orchestrates α-synuclein oligomer to fibril conversion
J. Santos, J. Cuellar, I. Pallares, E. J. Byrd, A. Lends, F. Moro, M. B. Abdul-Shukkoor, J. Pujols, L. Velasco-Carneros, F. Sobott, D. E. Otzen, A. N. Calabrese, A. Muga, J. S. Pedersen, A. Loquet, , S. Ventura
This study identifies an N-terminal motif in α-synuclein oligomers that drives fibril conversion and shows how a mutation disrupts this process, offering a new therapeutic target.
bioRxiv · Feb 10, 2023Biophysics