J. Santos

Toxicogenomic analysis of the carcinogenic potential of plastic additives

This study analyzes the carcinogenic potential of 2,712 plastic additives using toxicogenomic methods, finding over 150 known carcinogens and most lacking carcinogenicity data.

CRISPR/Cas9-based edition of frataxin gene in Dictyostelium discoideum for Friedreich's Ataxia disease modeling

This paper develops a Dictyostelium discoideum model for Friedreich's Ataxia by editing the fxn locus and assessing the effects of a human variant.

A targetable N-terminal motif orchestrates α-synuclein oligomer to fibril conversion

This study identifies an N-terminal motif in α-synuclein oligomers that drives fibril conversion and shows how a mutation disrupts this process, offering a new therapeutic target.

Paradox Found: Global Accounting of Lymphocyte Protein Synthesis

The paper measures protein synthesis rates in lymphocytes and finds that their in vivo elongation rates increase with activation, despite a high protein-to-ribosome ratio suggesting insufficient capacity for rapid division.

Microbes are potential key players in the evolution of life histories and aging in Caenorhabditis elegans

This study investigates how host-microbe interactions influence life history and aging in C. elegans, showing genotype-dependent effects on reproductive aging and survival.

Selection of Synthetic Proteins to Modulate the Human Frataxin Function

This study selects a synthetic protein, Affi_224, that modulates frataxin function with nanomolar affinity, showing potential for therapeutic applications in Friedreichs Ataxia.

The mycobacterial mutasome: composition and recruitment in live cells

This study identifies the molecular composition and function of the mycobacterial mutasome, showing that the ImuB-{beta} clamp interaction is essential for mutagenic DNA repair in mycobacteria.

Production of a Highly Immunogenic Antigen from SARS-CoV-2 by Covalent Coupling of the Receptor Binding Domain of Spike Protein to a Multimeric Carrier

This paper shows that coupling multiple SARS-CoV-2 RBD units to a multimeric carrier protein enhances immune response, leading to higher neutralizing antibody titers.

α-Helical peptidic scaffolds to target α-synuclein pathogenic species with high affinity and selectivity.

The paper identifies α-helical peptides that selectively bind and neutralize pathogenic α-synuclein species with high affinity, suggesting potential therapeutic and diagnostic applications.

Introducing selfisher: open source software for statistical analyses of fishing gear selectivity

The paper introduces selfisher, an R package for analyzing fishing gear selectivity data using statistical models with fixed and random effects, and demonstrates its application through case studies.

A High Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury during the COVID-19 pandemic

The paper identifies Fostamatinib as a potential repurposing drug for acute lung injury by reducing MUC1 protein levels in preclinical models.

Structural and Functional Comparison of SARS-CoV-2-Spike Receptor Binding Domain Produced in Pichia pastoris and Mammalian Cells

This study compares the structural and functional properties of SARS-CoV-2 Spike RBD produced in yeast and mammalian cells, finding similar stability but greater heterogeneity in yeast-produced RBD.

A new approach for quantifying phosphorus requirement in an Amazonian fish using CT-scanning

This study determines the dietary phosphorus requirement for tambaqui fish using growth data, mineralization, and blood chemistry parameters.

Exploring the Conformational Transition Between the Fully Folded and Locally Unfolded Substates of the Escherichia coli Thiol Peroxidase

This study investigates the conformational transition between fully folded and locally unfolded states of Escherichia coli thiol peroxidase using molecular dynamics simulations and identifies energy barriers and mutant effects on the transition.

How phenotypic convergence arises in experimental evolution

This study examines whether initially differentiated Drosophila subobscura populations converge to similar adaptive states after 60 generations in a common environment, finding persistent differentiation despite convergence patterns.