Plasmodium falciparum mitochondrial complex III, the target of atovaquone, is essential for progression to the transmissible sexual stages.
P. K. Sheokand, A. Muhleip, L. Sheiner
This study shows that Plasmodium falciparum complex III is essential for asexual stage survival and gametocyte maturation, supporting its role as a drug target.
bioRxiv · Jan 9, 2024 · PreprintCell Biology