Author

A. Amunts

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 5 Cell Biology· 1 Evolutionary Biology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:protein folding & dynamics· 5 Research Focus:cell type annotation· 4 Assay:cryo-EM· 4 Organism:human· 3 Assay:structural biology· 3 Approach:microscopy & imaging analysis· 2 Research Focus:protein structure prediction· 2

Frequent Co-Authors

Y. Itoh· 4 shared A. Naschberger· 3 shared V. Tobiasson· 3 shared A. Barrientos· 2 shared A. Marechal· 2 shared A. Muhleip· 2 shared R. Baradaran· 2 shared R. K. Flygaard· 2 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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4 shared papersBiochemistry

Y. Itoh

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Structure of the II2-III2-IV2 mitochondrial supercomplex from the parasite Perkinsus marinus

F. Wu, A. Muhleip, T. Gruhl, L. Sheiner, A. Marechal, A. Amunts

This study determines the structure of a unique II2-III2-IV2 mitochondrial supercomplex from Perkinsus marinus using cryo-EM, revealing novel subunit arrangements and functional features.

bioRxiv · May 25, 2024 · PreprintBiochemistry

Structure of mitoribosome reveals mechanism of mRNA binding, tRNA interactions with L1 stalk, roles of cofactors and rRNA modifications

V. Singh, Y. Itoh, S. Del'Olio, A. Hassan, A. Naschberger, R. K. Flygaard, Y. Nobe, K. Izumikawa, S. Aibara, J. Andrell, P. Whitford, A. Barrientos, M. Taoka, A. Amunts

The paper presents a high-resolution structure of the human mitoribosome, revealing mechanisms of mRNA binding, tRNA interactions, and roles of cofactors and rRNA modifications.

bioRxiv · May 24, 2023 · PreprintBiochemistry

METTL17 is an Fe-S cluster checkpoint for mitochondrial translation

T. Ast, Y. Itoh, S. Sadre, J. G. McCoy, G. Namkoong, I. Chicherin, P. R. Joshi, P. Kamenski, D. L. M. Suess, A. Amunts, V. K. Mootha

The paper identifies METTL17 as an Fe-S cluster checkpoint that regulates mitochondrial translation and bioenergetics in the absence of frataxin.

bioRxiv · Nov 24, 2022Cell Biology

Structural basis of mitochondrial membrane bending by I-II-III2-IV2 supercomplex

A. Muhleip, R. K. Flygaard, O. Haapanen, R. Baradaran, T. Gruhl, V. Tobiasson, A. Marechal, V. Sharma, A. Amunts

The paper reveals the structural basis of mitochondrial membrane bending by the I-II-III2-IV2 supercomplex using cryo-EM and molecular dynamics simulations.

bioRxiv · Jun 26, 2022 · PreprintBiochemistry

Structural basis of LRPPRC-SLIRP-dependent translation by the mitoribosome

V. Singh, J. C. Moran, Y. Itoh, I. C. Soto, F. Fontanesi, M. Couvillion, M. Huynen, S. Churchman, A. Barrientos, A. Amunts

The paper determines the cryo-EM structure of LRPPRC-SLIRP complex with mRNA and mitoribosome, showing its role in mRNA delivery and translation regulation.

bioRxiv · Jun 20, 2022Biochemistry

Algal photosystem I dimer and high resolution model of PSI:plastocyanin complex

A. Naschberger, L. Mosebach, V. Tobiasson, S. Kuhlgert, M. Scholz, A. Perez-Boerema, T. T. H. Ho, A. Vidal-Meireles, Y. Takahashi, M. Hippler, A. Amunts

The paper presents a cryo-EM structure of a homodimeric chloroplast PSI from Chlamydomonas reinhardtii, revealing its organization and interactions with plastocyanin and Lhca9.

bioRxiv · Aug 30, 2021 · PreprintPlant Biology

Interconnected assembly factors regulate the biogenesis of mitoribosomal large subunit

V. Tobiasson, O. Gahura, S. Aibara, R. Baradaran, A. Zikova, A. Amunts

The paper identifies 22 assembly factors involved in mitoribosomal large subunit biogenesis in Trypanosoma brucei, revealing their structural organization and functional roles.

bioRxiv · Jun 28, 2020Evolutionary Biology

Analysis of translating mitoribosome reveals functional characteristics of translation in mitochondria of fungi

Y. Itoh, A. Naschberger, N. Mortezaei, J. Herrmann, A. Amunts

The paper models the translating fungal mitoribosome and its assembly intermediate, revealing mechanisms of mRNA binding, tRNA translocation, and nascent polypeptide exit.

bioRxiv · Jan 31, 2020Biochemistry