Quantitative proteomics and phosphoproteomics of PPP2R5D variants reveal deregulation of RPS6 phosphorylation through converging signaling cascades
K. A. Smolen, C. M. Papke, M. R. Swingle, A. Musiyenko, C. Li, A. D. Camp, R. E. Honkanen, A. N. Kettenbach
The paper uses proteomics and phosphoproteomics to analyze PPP2R5D variants, finding RPS6 hyperphosphorylation and mTORC1 activation through different pathways in E198K and E420K variants.
bioRxiv · Mar 27, 2023 · PreprintCell Biology