A. Suzuki

Sildenafil amplifies calcium influx and insulin secretion in pancreatic β cells

This study shows sildenafil enhances insulin secretion in pancreatic β cells by increasing calcium influx, independent of L-type Ca2+ channels and PDE5.

Insights into the complex formation of a trimeric autotransporter adhesin with a peptidoglycan-binding periplasmic protein

This study identifies a stable complex between a trimeric autotransporter adhesin and a peptidoglycan-binding periplasmic protein, revealing structural and interaction details.

Basement membrane extract potentiates the endochondral ossification phenotype of bone marrow-derived mesenchymal stem cell-based cartilage organoids

This study shows that basement membrane extract enhances endochondral ossification in bone marrow-derived mesenchymal stem cell-based cartilage organoids by altering gene expression and pathway activation.

Identification of novel autophagy inducers by accelerating lysosomal clustering against Parkinson's disease

This study identifies six drugs that enhance autophagy by promoting lysosomal clustering, which facilitates the degradation of protein aggregates associated with Parkinson's disease.

Transcription factor-mediated direct cellular reprogramming yields cell-type specific DNA methylation signature

This study investigates DNA methylation changes during direct reprogramming of mouse embryonic fibroblasts to induced intestinal stem cells, showing similar methylation states between organoid-forming cells and minimal impact on gene expression.

Extended regulation interface coupled to the allosteric network and disease mutations in the PP2A-B56δ holoenzyme

The paper investigates the structural and functional dynamics of the PP2A-B56δ holoenzyme, showing how mutations linked to intellectual disability affect its allosteric network and phosphorylation rates.

Murine breast cancers disorganize the liver transcriptome in zonated manners

This study uses spatial transcriptomics to show that breast cancers disrupt liver zonation patterns, affecting specific metabolic and immune pathways in a zonated manner.

Signaling through FcγRIIA and the C5a-C5aR pathway mediates platelet hyperactivation in COVID-19

This study identifies FcγRIIA and C5a-C5aR pathways as mediators of platelet hyperactivation in COVID-19 patients, showing their role in thrombotic complications.

Immune cell multi-omics analysis reveals contribution of oxidative phosphorylation to B cell functions and organ damage of lupus

The paper identifies oxidative phosphorylation (OXPHOS) as a key driver in SLE B cells, linking mitochondrial dysfunction to immune signaling and organ damage.

MTCL2 promotes asymmetric microtubule organizationby crosslinking microtubules on the Golgi membrane

This study identifies MTCL2 as a protein that crosslinks microtubules on the Golgi membrane, promoting asymmetric microtubule organization and supporting directional migration.

MTCL2 promotes asymmetric microtubule organizationby crosslinking microtubules on the Golgi membrane

This study identifies MTCL2 as a protein that crosslinks microtubules on the Golgi membrane, promoting asymmetric microtubule organization and supporting directional migration.

Two DNA binding domains of Mga act in combination to suppress ectopic activation of meiosis-related genes in mouse embryonic stem cells

The paper shows that both DNA-binding domains of Mga repress meiosis-related genes in mouse ESCs, with bHLHZ playing a key role in suppressing Meiosin expression.

Parsing multiomics landscape of activated synovial fibroblasts highlights drug targets linked to genetic risk of rheumatoid arthritis

This study analyzes multi-omics data from activated synovial fibroblasts to identify genetic risk factors and potential drug targets for rheumatoid arthritis.

Phosphorylation and dephosphorylation of Ser852 and Ser889 control clustering, localization, and function of PAR-3

This study shows that phosphorylation and dephosphorylation of PAR-3 at Ser852 and Ser889 regulate its clustering, localization, and function in cell polarity and junction formation.

In silico APC/C substrate discovery reveals cell cycle degradation of chromatin regulators including UHRF1

The paper predicts APC/C substrates in silico, identifies chromatin regulators as substrates, and shows their cell cycle-dependent degradation and impact on DNA methylation.

PIKfyve deficiency in myeloid cells impairs lysosomal homeostasis in macrophages and promotes systemic inflammation in mice

This study shows that PIKfyve deficiency in myeloid cells impairs lysosomal function, leading to systemic inflammation and tissue infiltration in mice.

LITE microscopy: a technique for high numerical aperture, low photobleaching fluorescence imaging

The paper introduces LITE microscopy, a technique that improves resolution and brightness while reducing photodamage in fluorescence imaging.