Vascularized tumor on a microfluidic chip to study mechanisms promoting tumor neovascularization and vascular targeted therapies
M. Skubal, B. E. Mc Larney, N. B. Phung, J. C. Desmaras, A.-V. Dozic, A. Volpe, A. Ogirala, C. M. L. Machado, J. Djibankov, V. Ponomarev, J. Grimm
This study develops a microfluidic chip model of vascularized tumors to evaluate angiogenesis and vascular-targeted therapies, showing bevacizumab disrupts tumor-vessel interactions and enables rapid drug assessment.
bioRxiv · Aug 7, 2023Cancer Biology