Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture
E. G. Alvarez, J. Demeulemeester, C. Jolly, D. Garcia-Souto, P. Otero, A. Pequeno, J. Zamora, M. Tojo, J. Temes, A. Baez-Ortega, B. Rodriguez-Martin, Y. Li, A. Oitaben, A. L. Bruzos, M. Martinez-Fernandez, , J. Tubio
The paper identifies a mutational mechanism in hepatocellular carcinoma driven by Hepatitis B virus DNA integration, leading to genomic restructuring and oncogenic rearrangements.
bioRxiv · Apr 19, 2021Cancer Biology