Discovery of Chlorofluoroacetamide-Based Covalent Inhibitors for SARS-CoV-2 3CL Protease
Y. Hirose, N. Shindo, M. Mori, S. Onitsuka, H. Isogai, R. Hamada, T. Hiramoto, J. Ochi, D. Takahashi, T. Ueda, J. M. M. Caaveiro, Y. Yoshida, S. Ohdo, N. Matsunaga, S. Toba, , A. Ojida
The paper identifies a new class of covalent inhibitors for SARS-CoV-2 3CL protease with chlorofluoroacetamide warhead, showing potent antiviral activity comparable to nirmatrelvir.
bioRxiv · Jun 5, 2022Biochemistry