M. Mori

Zinc finger domains bind low-complexity domain polymers

This study shows zinc finger domains bind low-complexity domain polymers in a cross-β-dependent manner, suppressing polymer formation and preferentially recognizing polymeric LC domains.

Proteome partitioning constraints on long-term laboratory evolution

The paper investigates proteome remodeling in bacterial lineages over 40,000 generations and identifies sector-specific adaptations in metabolic enzyme expression.

Establishing a comprehensive web-based analysis platform for Nicotiana benthamiana genome and transcriptome

The paper develops a web-based platform for analyzing Nicotiana benthamiana genome and transcriptome data, enabling gene expression visualization, phylogenetic analysis, and functional enrichment.

Spatiotemporal development of growth and death zones in expanding bacterial colonies driven by emergent nutrient dynamics

This study shows that bacterial colony expansion is driven by mechanical constraints and nutrient gradients, with cell death occurring in a distinct zone due to glucose depletion and anaerobiosis.

Genome-resolved meta-omics unveils rock-hosted lifestyle of enigmatic DPANN archaea

This study investigates the lifestyle of DPANN archaea in rock-hosted environments using genome-resolved meta-omics, revealing a symbiotic lifestyle and ecological interactions with bacteria and minerals.

Functional and long-lived melanocytes from human pluripotent stem cells with transient ectopic expression of JMJD3

This study generates functional and long-lived melanocytes from human pluripotent stem cells using transient JMJD3 expression, showing melanogenesis and engraftability in mice.

A developmental program that regulates mammalian organ size offsets evolutionary distance

The paper identifies a conserved molecular program regulating organ size across species, showing higher homology in humans and pigs than in closely related mice.

Discovery of Chlorofluoroacetamide-Based Covalent Inhibitors for SARS-CoV-2 3CL Protease

The paper identifies a new class of covalent inhibitors for SARS-CoV-2 3CL protease with chlorofluoroacetamide warhead, showing potent antiviral activity comparable to nirmatrelvir.

Molecular evidence of chemical disguise by the socially parasitic spiny ant Polyrhachis lamellidens (Hymenoptera: Formicidae) when invading a host colony

This study shows that the spiny ant Polyrhachis lamellidens acquires host cuticular hydrocarbons through rubbing behavior to disguise itself and avoid aggression during colony invasion.

A local translation program regulates centriole amplification in the airway epithelium

This study identifies Tnrc6a as a regulator of centriole amplification and multicilia formation through local translation of miRNA targets in airway epithelial cells.

Prom1 and Notch regulate ciliary length and dynamics in multiciliated cells of the airway epithelium

This study identifies Prom1 and Notch as regulators of ciliary length and dynamics in multiciliated airway epithelial cells, contributing to mucociliary clearance and lung defense.

Fungal effector SIB1 of Colletotrichum orbiculare has unique structural features and can suppress plant immunity in Nicotiana benthamiana

This study identifies SIB1, a fungal effector from Colletotrichum orbiculare, which suppresses plant immunity in N. benthamiana by inhibiting ROS and cell death responses.

Sub-lethal radiation-induced senescence impairs resolution programs and drives cardiovascular inflammation

This study shows sub-lethal radiation induces macrophage senescence, impairing efferocytosis and promoting cardiovascular inflammation, with RvD1 treatment reversing these effects.

Red-beet betalain pigment inhibits amyloid-β aggregation and toxicity in amyloid-β expressing Caenorhabditis elegans model

This study shows red-beet betalain pigments inhibit amyloid-β aggregation and toxicity in a C. elegans model of Alzheimer's disease.

Production of ORF8 protein from SARS-CoV-2 using an inducible virus-mediated expression system in suspension-cultured tobacco BY-2 cells

This study produces SARS-CoV-2 ORF8 protein in a chemically inducible system using tobacco BY-2 cells, confirming its dimeric structure and glycosylation.

Myosin 10 and a Cytoneme-Localized Ligand Complex Promote Morphogen Transport

The paper shows Myosin 10 and BOC/CDON co-receptor facilitate SHH morphogen transport via cytonemes.

CTDSP1 inhibitor rabeprazole regulates DNA-PKcs dependent topoisomerase I degradation and irinotecan drug resistance in colorectal cancer

This study shows that rabeprazole inhibits CTDSP1, which promotes irinotecan resistance in colorectal cancer by enhancing DNA-PKcs-mediated topoisomerase I degradation.

Rupture of nuclear envelope in starfish oocytes proceeds by F-actin-driven segregation of pore-dense and pore-free membranes

This study shows that F-actin, driven by Arp2/3, causes nuclear envelope rupture in starfish oocytes by segregating pore-dense and pore-free membranes.

F-actin patches nucleated on chromosomes coordinate capture by microtubules in oocyte meiosis

The paper shows F-actin patches coordinate with microtubules to ensure proper chromosome capture during oocyte meiosis, preventing aneuploidy.