T. Ueda

Relationship between Protein Conformational Stability and Its Immunogenicity When Administering Antigens to Mice Using Adjuvants

This study examines how protein conformational stability affects immunogenicity in mice when antigens are administered with adjuvants, focusing on the CH2 domain.

Harnessing deep learning to analyze cryptic morphological variability of Marchantia polymorpha

This paper uses deep learning to classify sex in Marchantia polymorpha gemmalings, revealing that morphological differences are due to autosomal variation rather than sexual dimorphism.

Organism-Wide Analysis of Sepsis Reveals Mechanisms of Systemic Inflammation

The paper uses mouse models to map sepsis' effects across organs, identifying cytokine circuits and PLA2G5's role in hemolysis and organ failure.

Genetic and phosphoproteomic basis of LysM-mediated immune signaling in Marchantia polymorpha highlights conserved elements and new aspect of pattern-triggered immunity in land plants

This study identifies LysM receptor components and phosphoproteomic regulators of PTI in M. polymorpha, revealing conserved and novel elements of plant immune signaling.

Plant specific armadillo repeat kinesin directs organelle transport and microtubule convergence to promote tip growth

This study identifies MpARK, a plant-specific kinesin, as essential for organelle transport and microtubule convergence in tip-growing rhizoids, supporting plant anchorage and growth.

Discovery of Chlorofluoroacetamide-Based Covalent Inhibitors for SARS-CoV-2 3CL Protease

The paper identifies a new class of covalent inhibitors for SARS-CoV-2 3CL protease with chlorofluoroacetamide warhead, showing potent antiviral activity comparable to nirmatrelvir.

Bryophyte spermiogenesis occurs through multimode autophagic and nonautophagic degradation

The paper investigates mitochondrial reorganization during spermiogenesis in Marchantia polymorpha, revealing autophagic and nonautophagic degradation mechanisms.

Phylogenetic distribution and expression pattern analyses identified a divergent basal body assembly protein involved in land plant spermatogenesis

The paper identifies a divergent BLD10 protein involved in land plant spermatogenesis through evolutionary and molecular genetic analyses.

Remodeling of organelles and microtubules during spermiogenesis in the liverwort Marchantia polymorpha

This study classifies spermiogenesis stages in liverwort Marchantia polymorpha and characterizes organelle and microtubule remodeling during sperm development.

Lipid nanodiscs facilitate the identification of a fragment compound inhibiting the enzymatic activity of the bacterial membrane protein MsbA.

This study uses lipid nanodiscs and surface plasmon resonance to identify a fragment compound that inhibits MsbA's ATPase activity, suggesting a pathway for developing stronger inhibitors.

Multi-state structure determination and dynamics analysis reveals a new ubiquitin-recognition mechanism in yeast ubiquitin C-terminal hydrolase

The paper develops an NMR method to determine multi-state structures of proteins and applies it to yeast ubiquitin hydrolase 1, revealing dynamic motions critical for ubiquitin recognition and proteolysis.

The SYP123-VAMP727 SNARE complex is involved in the delivery of inner cell wall components to the root hair shank in Arabidopsis

The paper identifies SYP123 and VAMP727 as components of a SNARE complex involved in delivering inner cell wall materials to the root hair shank in Arabidopsis.

The Arabidopsis V-ATPase is localized to the TGN/EE via a seed plant specific motif and acts in a partially redundant manner with the tonoplast enzyme

This study identifies a seed plant-specific motif in Arabidopsis VHA-a1 that targets the V-ATPase to the TGN/EE and shows partial functional redundancy with tonoplast-localized VHA-a2 and VHA-a3.

Enhanced recovery of CD9-positive extracellular vesicles from human specimens by chelating reagent

This study demonstrates that a chelating reagent improves the recovery of CD9-positive extracellular vesicles from biological samples through immunoprecipitation.

Temperature-dependent fasciation mutants connect mitochondrial RNA processing to the control of cell proliferation during lateral root morphogenesis

Switching secretory pathway direction for organelle acquisition in plants

The paper identifies a mechanism in liverworts for acquiring oil bodies through switching secretory pathway direction during cellular phase transitions.

Oil body formation in Marchantia polymorpha is controlled by MpC1HDZ and serves as a defense against arthropod herbivores

This study identifies MpC1HDZ as a transcription factor controlling oil body formation in liverworts, which functions as a defense against herbivores rather than abiotic stress.