Discovery of Chlorofluoroacetamide-Based Covalent Inhibitors for SARS-CoV-2 3CL Protease
Y. Hirose, N. Shindo, M. Mori…·A. Ojida
The paper identifies a new class of covalent inhibitors for SARS-CoV-2 3CL protease with chlorofluoroacetamide warhead, showing potent antiviral activity comparable to nirmatrelvir.