BiochemistrybioRxiv
Novel allosteric mechanism of dual p53/MDM2 and p53/MDM4 inhibition by a small molecule
V. Grinkevich, V. Aparna, K. Fawkner…·J. E. Zawacka-Pankau
This paper identifies a novel allosteric mechanism by which RITA and PpIX inhibit p53/MDM2 and p53/MDM4 interactions, offering a new approach for p53 reactivation in cancer therapy.
DOI 10.3389/fmolb.2022.823195