Genetic immunodeficiency and autoimmune disease reveal distinct roles of Hem1 in the WAVE2 and mTORC2 complexes
W. A. Comrie, M. C. Poli, S. A. Cook, M. Similuk, A. Oler, A. J. Faruqi, D. B. Kuhns, S. Yang, A. F. Carisey, B. Fournier, D. E. Anderson, S. Price, W. A. Chahla, A. Vargas-Hernandez, L. R. Forbes, , M. J. Lenardo
Hem1 loss-of-function mutations cause congenital immunodysregulation by disrupting WAVE2 and mTORC2 complexes, leading to immunodeficiency and immune hyperresponsiveness.
bioRxiv · Jul 4, 2019 · PreprintImmunology