B. Chen

Leveraging protein language and structural modelsfor early prediction of antibodies with fast clearance

This paper predicts antibody clearance using deep learning and physicochemical features, showing comparable performance to physicochemical models.

On the discovered Cancer Driving Nucleotides (CDNs)-Distributions across genes, cancer types and patients

This study identifies Cancer Driving Nucleotides (CDNs) across cancer types and patients, finding that most remain unidentified and highlights the need for larger sample sizes to improve detection.

The theory of massively repeated evolution and full identifications of Cancer Driving Nucleotides (CDNs)

This study develops a theory to identify Cancer Driving Nucleotides (CDNs) by analyzing mutation recurrence across large cancer datasets, finding that mutations recurring at least three times are likely CDNs.

Behavioral impairments are linked to neuroinflammation in mice with Cerebral Cavernous Malformation disease

This study shows that CCM lesions in mice cause behavioral impairments linked to neuroinflammation, affecting motor coordination and memory.

Endothelial cannabinoid CB1 receptor deficiency reduces arterial inflammation and lipid uptake in response to atheroprone shear stress

This paper shows that blocking endothelial CB1 receptors reduces arterial inflammation and lipid uptake under atheroprone shear stress, suggesting potential therapeutic benefits for atherosclerosis.

Quantitative intra-Golgi transport and organization data suggest the stable compartment nature of the Golgi

The paper challenges the classical cisternal progression model by showing that intra-Golgi transport velocity varies and Golgi residence times differ for different cargos, suggesting a stable compartment model.

Ascorbate depletion increases quiescence and self-renewal potential in hematopoietic stem cells and multipotent progenitors

ELO-6 expression predicts longevity in isogenic populations of Caenorhabditis elegans

This study identifies ELO-6 expression as a predictor of longevity in isogenic C. elegans populations and shows its regulation by PQM-1.

Functional characterization of Lipid storage droplets 1 (LSD1) in growth and lipolysis of Hermetia illucens

This study investigates the role of LSD1 in lipid metabolism of Hermetia illucens, finding it promotes larval growth without affecting fat content or development.

Adaptive Optics in an Oblique Plane Microscope

This paper demonstrates adaptive optics in an oblique plane microscope, improving resolution and signal strength in zebrafish embryos.

Structural basis for Retriever-SNX17 assembly and endosomal sorting

This study determines the structure of the Retriever-SNX17 complex using cryo-EM, revealing how SNX17 interacts with Retriever to facilitate endosomal sorting of cargo proteins.

Heterogeneity and evolution of DNA mutation rates in microsatellite stable colorectal cancer

The paper measures mutation rates in microsatellite stable colorectal cancers and finds they vary between tumors and increase during metastasis.

Construction and application of a technical platform for determining cell cycle- and autophagy-associated cellular accumulation of lipid-based nanoparticles

This study constructs a technical platform to investigate cell cycle- and autophagy-related nanoparticle accumulation, revealing distinct accumulation patterns in specific cell cycle phases.

Molecular chaperone BiP controls activity of the ER stress sensor Ire1 through interactions with its oligomers

This study shows BiP directly interacts with Ire1 oligomers to regulate its activation, controlling ER stress response by modulating Ire1-LD oligomerization.

Clearance of protein aggregates during cell division

The paper investigates how protein aggregates are cleared during cell division, finding that ER reorganization and BiP-mediated clearance occur during mitosis and cytokinesis.

navigate: an open-source platform for smart light-sheet microscopy.

navigate provides an open-source platform for smart light-sheet microscopy, enabling automated and user-friendly LSFM workflows without requiring specialized expertise.

RNA Splicing Junction Landscape Reveals Abundant Tumor-Specific Transcripts in Human Cancer

This study analyzes RNA splicing junctions in 34,775 samples to identify 29,051 tumor-specific transcripts linked to cancer stemness, poor prognosis, and immunotherapy targets.

BRD4-mediated epigenetic regulation of endoplasmic reticulum-mitochondria contact sites is governed by the mitochondrial complex III

The paper identifies fedratinib as a drug that increases endoplasmic reticulum-mitochondria contact sites by inhibiting BRD4, revealing a novel epigenetic pathway linking ERMCS to cellular metabolism.

Dynamic evolution of infarct volumes at MRI in ischemic stroke due to large vessel occlusion

This study identifies three infarct growth phenotypes in ischemic stroke patients based on MRI data and shows they predict 3-month clinical outcomes.

Boosting bactericidal immunity of a recombinant Mycobacterium smegmatis strain via zinc-dependent ribosomal proteins

This study shows that IKEPLUS, a recombinant Mycobacterium smegmatis strain, provides better protection against Mtb infection than BCG in mice when grown in low zinc media.

Ultrasound programmable hydrogen-bonded organic frameworks for sono-chemogenetics

This paper introduces ultrasound programmable hydrogen-bonded organic frameworks (HOFs) for targeted drug release and neural circuit modulation in deep brain regions.

Specific cPRC1 complexes are co-opted to mediate oncogenic gene repression in diffuse midline glioma

The paper identifies specific cPRC1 complexes, CBX4/PCGF4, that mediate oncogenic gene repression in DMG cells downstream of H3K27M mutation.

Melatonin serves as a novel treatment in cystic fibrosis and inhibits cystic fibrosis through TGF-β1/Smad and EMT

This study shows melatonin reduces bladder fibrosis by inhibiting the TGF-β1/Smad pathway and epithelial-mesenchymal transition (EMT) in both in vitro and in vivo models.

Epigenetic heritability of cell plasticity drives cancer drug resistance through one-to-many genotype to phenotype mapping

The paper shows how epigenetic heritability of cell plasticity contributes to cancer drug resistance through a one-to-many genotype-to-phenotype mapping.

Mitochondrial One-Carbon Metabolism is Required for TGF-β-Induced Glycine Synthesis and Collagen Protein Production

This study shows that mitochondrial one-carbon metabolism is essential for TGF-β-induced glycine synthesis and collagen production in lung fibroblasts, suggesting MTHFD2 inhibitors could treat IPF.

Integrative analysis of the methylome and transcriptome of tomato fruit (Solanum lycopersicum L.) induced by postharvest handling

This study examines how postharvest handling affects the methylome and transcriptome of tomato fruit, revealing epigenetic and gene expression changes linked to ripening speed and quality.

Harnessing Landrace Diversity Empowers Wheat Breeding for Climate Resilience

This study uses landrace diversity in wheat to identify genetic resources for climate resilience and improved traits, providing a framework for crop improvement.

TAPIR: a T-cell receptor language model for predicting rare and novel targets

TAPIR predicts TCR-target interactions, including novel targets, using a deep CNN model trained on diverse TCR sequences and targets.

Wall-following: phylogenetic context of an enhanced behaviour in stygomorphic Sinocyclocheilus (Cypriniformes: Cyprinidae) cavefishes

This study examines wall-following behavior in Sinocyclocheilus cavefish, finding that eyeless species exhibit enhanced behavior compared to sighted ones, with phylogenetic patterns linking behavior intensity to subterranean adaptation.

Metabolites with benzene ring from sugarcane leaf play important role in plant-Spodoptera frugiperda interaction

The paper identifies benzene-ring containing metabolites in sugarcane that influence Spodoptera frugiperda behavior and development, with some promoting insect growth and others repelling them.