Author

A. Oo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:genetic perturbation / CRISPR· 2 Organism:human· 2 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

B. Kim· 2 shared K. Schott· 2 shared M. Schüssler· 2 shared N. V. Fuchs· 2 shared P. Rauch· 2 shared R. König· 2 shared M. Zahadi· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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2 shared papersMicrobiology

B. Kim

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Gene editing of SAMHD1 in macrophage-like cells reveals complex relationships between SAMHD1 phospho-regulation, HIV-1 restriction and cellular dNTP levels

M. Schüssler, K. Schott, N. V. Fuchs, A. Oo, M. Zahadi, P. Rauch, B. Kim, R. König

This study uses CRISPR/Cas9 to edit SAMHD1 in macrophage-like cells, revealing that T592 phosphorylation affects HIV-1 restriction and dNTP levels independently.

bioRxiv · Aug 24, 2023Microbiology

CRISPR/Cas9 knock-in strategy to evaluate phospho-regulation of SAMHD1

M. Schüssler, P. Rauch, K. Schott, A. Oo, N. V. Fuchs, B. Kim, R. König

This study uses CRISPR/Cas9 knock-in to show that T592 dephosphorylation is required for SAMHD1's anti-viral activity, but not for dNTP depletion, suggesting uncoupling of these functions.

bioRxiv · Jan 4, 2022 · PreprintMicrobiology