MicrobiologybioRxiv
Gene editing of SAMHD1 in macrophage-like cells reveals complex relationships between SAMHD1 phospho-regulation, HIV-1 restriction and cellular dNTP levels
M. Schüssler, K. Schott, N. V. Fuchs…·R. König
This study uses CRISPR/Cas9 to edit SAMHD1 in macrophage-like cells, revealing that T592 phosphorylation affects HIV-1 restriction and dNTP levels independently.
DOI 10.1128/mbio.02252-23