Author

K. Schott

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:gene regulatory network inference· 2 Approach:genetic perturbation / CRISPR· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Oo· 2 shared B. Kim· 2 shared M. Schüssler· 2 shared N. V. Fuchs· 2 shared P. Rauch· 2 shared R. König· 2 shared A. Jeron· 1 shared A. Kroeger· 1 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersMicrobiology

A. Oo

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Gene editing of SAMHD1 in macrophage-like cells reveals complex relationships between SAMHD1 phospho-regulation, HIV-1 restriction and cellular dNTP levels

M. Schüssler, K. Schott, N. V. Fuchs, A. Oo, M. Zahadi, P. Rauch, B. Kim, R. König

This study uses CRISPR/Cas9 to edit SAMHD1 in macrophage-like cells, revealing that T592 phosphorylation affects HIV-1 restriction and dNTP levels independently.

bioRxiv · Aug 24, 2023Microbiology

Epigenetic changes and serotype-specific interferon-responses of lung epithelial cells in late post-influenza pneumococcal pneumonia

J. D. Boehme, A. Jeron, K. Schultz, L. Melcher, K. Schott, E. Gelmez, A. Kroeger, S. Stegemann-Koniszewski, D. Bruder

This study investigates how IAV infection alters the transcriptional and epigenetic responses of lung epithelial cells to pneumococcal serotypes, revealing serotype-specific interferon responses and epigenetic changes.

bioRxiv · Jun 28, 2023 · PreprintImmunology

Unplugging lateral fenestrations of NALCN reveals a hidden drug binding site within the pore module

K. Schott, S. G. Usher, O. Serra, V. Carnevale, S. Pless, H. C. Chua

This paper identifies a hidden drug binding site in NALCN by unplugging its lateral fenestrations and shows that 2-APB and phenytoin access the pore through distinct pathways.

bioRxiv · Apr 12, 2023 · PreprintPharmacology & Toxicology

CRISPR/Cas9 knock-in strategy to evaluate phospho-regulation of SAMHD1

M. Schüssler, P. Rauch, K. Schott, A. Oo, N. V. Fuchs, B. Kim, R. König

This study uses CRISPR/Cas9 knock-in to show that T592 dephosphorylation is required for SAMHD1's anti-viral activity, but not for dNTP depletion, suggesting uncoupling of these functions.

bioRxiv · Jan 4, 2022 · PreprintMicrobiology