Quality control of HLA-DR molecules by the lysosomal aspartyl protease, cathepsin D
N. Shah, S. McDonald, C. T. A. Parker, R. W. M. Robinson, A. Oomatia, A. De Riva, M. J. Deery, E. D. Mellins, R. Busch
This study identifies cathepsin D as a protease responsible for degrading HLA-DR molecules that lack bound peptide, regulating their lysosomal disposal and lifespan.
bioRxiv · Mar 25, 2020 · PreprintBiochemistry