BiochemistrybioRxivPreprint
Quality control of HLA-DR molecules by the lysosomal aspartyl protease, cathepsin D
N. Shah, S. McDonald, C. T. A. Parker…·R. Busch
This study identifies cathepsin D as a protease responsible for degrading HLA-DR molecules that lack bound peptide, regulating their lysosomal disposal and lifespan.