Tadpole-like conformations of huntingtin exon 1 with expanded polyglutamine engenders novel interactions in cells
E. A. Newcombe, K. M. Ruff, A. Sethi, A. Ormsby, Y. M. Ramdzan, A. Fox, A. W. Purcell, P. R. Gooley, R. V. Pappu, D. M. Hatters
The paper investigates the structure of Httex1 with expanded polyQ and finds that its tadpole-like conformation increases interactions in cells, potentially contributing to neurotoxicity.
bioRxiv · Aug 22, 2017Biochemistry