A. Fox

Adipose microenvironment promotes hypersialylation of ovarian cancer cells

This study shows that the adipose microenvironment increases sialylation in ovarian cancer cells, promoting tumor growth in immune-dependent settings.

Interplay between particle size and microbial ecology in the gut microbiome

This study investigates the factors influencing fecal particle size in humans and finds that gut microbiota, rather than diet or behavior, primarily shape particle size.

Detection of tomato brown rugose fruit virus in environmental residues: the importance of contextualizing test results

This study shows ToBRFV is widely detected in environmental samples, highlighting the need for contextual information to interpret test results accurately.

Plant species richness and the root economics space drive soil fungal communities

The paper shows that plant species richness and root economics space axes influence soil fungal community composition in a grassland experiment.

Adipose-derived exosomal miR-421 targets CBX7 and promotes metastatic potential in ovarian cancer cells

This study identifies adipose-derived exosomal miR-421 as a regulator of CBX7 expression, promoting ovarian cancer metastasis by inducing epigenetic changes.

Design of a low-cost photomodulator for in vivo photoactivation of a mGluR5 inhibitor

This paper designs a low-cost photomodulator for in vivo photoactivation of a mGluR5 inhibitor, demonstrating its effectiveness in reducing pain response in rats.

Immune modulation of innate and adaptive responses restores immune surveillance and establishes anti-tumor immunological memory

This paper develops CARG-2020, a virus-like-vesicle that modulates immune responses to enhance anti-tumor immunity and establish immunological memory in ovarian cancer.

In Vivo Antiviral Efficacy of LCTG-002, a Pooled, Purified Human Milk Secretory IgA product, Against SARS-CoV-2 in a Murine Model of COVID-19

This study evaluates LCTG-002, a purified human milk sIgA product, showing it effectively reduces SARS-CoV-2 viral burden in mice.

Geometric variation of the human tibia-fibula: A public dataset of tibia-fibula surface meshes and statistical shape model

The paper develops a statistical shape model of the human tibia-fibula and provides an open-source dataset with associated code for analysis.

Impact of IgG isotype on the induction of antibody-dependent cellular phagocytosis of HIV by human milk leukocytes

This study investigates how different IgG isotypes in human milk influence antibody-dependent cellular phagocytosis (ADCP) of HIV by milk leukocytes, finding isotype-specific effects on phagocyte activity.

Within-host evolutionary dynamics of seasonal and pandemic human influenza A viruses in young children

This study examines within-host evolutionary dynamics of seasonal and pandemic influenza A viruses in young children, finding that nonsynonymous mutations decrease over time in A/H1N1pdm09 but increase in A/H3N2 due to mutation-selection balance.

PolyA-modulating antisense oligonucleotides reveal opposing functions for long non-coding RNA NEAT1 isoforms in neuroblastoma

The paper develops antisense oligonucleotides to modulate NEAT1 isoform ratios in neuroblastoma, showing increased NEAT1_2 and reduced cell viability.

A Whole Virion Vaccine for COVID-19 Produced Via a Novel Inactivation Method: Results from Animal Challenge Model Studies

This paper evaluates a novel inactivated whole virion COVID-19 vaccine (SolaVAX) in hamsters, showing its ability to induce neutralizing antibodies and protect against SARS-CoV-2 infection.

Impaired carotid body hypoxic sensing in mice deficient in olfactory receptor 78

This study investigates the role of Olfr78 in carotid body hypoxic sensing using knockout mice, finding impaired hypoxic responses but normal CO2 responses.

Tadpole-like conformations of huntingtin exon 1 with expanded polyglutamine engenders novel interactions in cells

The paper investigates the structure of Httex1 with expanded polyQ and finds that its tadpole-like conformation increases interactions in cells, potentially contributing to neurotoxicity.