A. Sethi

PIP-Seq identifies novel heterogeneous lung innate lymphocyte population activation after combustion product exposure

The paper introduces PIP-Seq to study lung ILC activation after exposure to environmental toxins, identifying novel ILC subsets and activation pathways.

Cell invasive amyloid assemblies from SARS-CoV-2 peptides can form multiple polymorphs with varying neurotoxicity

This study investigates how SARS-CoV-2 peptides form amyloid assemblies with varying neurotoxicity and polymorphic structures, showing that aggregation conditions influence toxicity and cellular uptake.

The replicative helicase CMG is required for the divergence of cell fates during asymmetric cell division in vivo

The paper identifies a role for the CMG helicase in promoting transcriptional divergence during asymmetric cell division in C. elegans, independent of its DNA unwinding function.

Regulatory T cells control type 1-driven immunopathology restraining GM-CSF-producing helper T cells

This study identifies GM-CSF-producing helper T cells as drivers of immunopathology, showing Treg cells restrain them to prevent tissue damage in mice.

Single-cell analysis reveals inter- and intratumour heterogeneity in metastatic breast cancer

This study uses single-cell RNA-Seq to identify molecular states and partial EMT phenotypes in breast cancer tumours and metastases, revealing common transcription factors across patients.

Structural insights into the modes of relaxin-binding and tethered-agonist activation of RXFP1 and RXFP2

The paper identifies a conserved motif critical for RXFP1 and RXFP2 activation, showing distinct structural roles in receptor activity.

Transcriptional analysis of peripheral memory T cells reveals Parkinson's disease-specific gene signatures

The paper identifies PD-specific gene signatures in peripheral memory T cells by analyzing RNA-seq data from PD patients and healthy controls.

Membrane permeabilization is mediated by distinct epitopes in mouse and human orthologs of the necroptosis effector, MLKL

The paper identifies distinct membrane binding epitopes in mouse and human MLKL orthologs that mediate necroptosis, revealing differences in their structural and functional mechanisms.

Transcriptome and Chromatin Landscape of iNKT cells are Shaped by Subset Differentiation and Antigen Exposure

This study examines how iNKT cell subsets change in gene programs and chromatin structure across tissues and after antigen exposure, revealing long-term adaptability.

Tadpole-like conformations of huntingtin exon 1 with expanded polyglutamine engenders novel interactions in cells

The paper investigates the structure of Httex1 with expanded polyQ and finds that its tadpole-like conformation increases interactions in cells, potentially contributing to neurotoxicity.