A. Paldi

Metabolic adaptation pilots the differentiation of human hematopoietic cells

The paper investigates how metabolic perturbations affect chromatin structure and gene expression during human hematopoietic cell differentiation.

An Image-Guided Microfluidic System for Single-Cell Lineage Tracking

This paper introduces a microfluidic system for single-cell lineage tracking, demonstrating its ability to isolate and analyze sister cells with high viability for downstream RNA sequencing.

Differentiation is accompanied by a progressive loss in transcriptional memory

The paper quantifies how transcriptional memory decreases during differentiation by comparing related and unrelated cells across generations.

Global genome decompaction leads to stochastic activation of gene expression as a first step toward fate commitment in human hematopoietic stem cells.

Integrated time-lapse and single-cell transcription studies highlight the variable and dynamic nature of human hematopoietic cell fate commitment.

The paper integrates single-cell transcriptional data with time-lapse microscopy to show dynamic and variable hematopoietic cell fate commitment, revealing non-binary lineage decisions.