S. Laxman

Metabolic adaptation pilots the differentiation of human hematopoietic cells

The paper investigates how metabolic perturbations affect chromatin structure and gene expression during human hematopoietic cell differentiation.

Aedes aegypti eggs use rewired polyamine and lipid metabolism to survive extreme desiccation

This study identifies polyamine and lipid metabolism rewiring in Aedes aegypti eggs that enable survival of extreme desiccation and subsequent hatching.

The deubiquitinase Ubp3/Usp10 constrains glucose-mediated mitochondrial repression via phosphate budgeting

The paper identifies Ubp3/Usp10 as a deubiquitinase that limits mitochondrial activation in high glucose by regulating phosphate availability through glycolytic flux.

Methionine uptake via SLC43A2 transporter is essential for regulatory T lymphocyte survival

The paper identifies methionine uptake via SLC43A2 as essential for Treg survival during IL-2 deprivation, regulated by Notch1.

Methylated PP2A stabilizes Gcn4 to enable a methionine-induced anabolic program

The paper identifies a methionine-induced mechanism where Ppm1-mediated PP2A methylation stabilizes Gcn4, enabling anabolic growth programs.

Metabolite plasticity drives carbon-nitrogen resource budgeting to enable division of labor in a clonal community

The paper shows that aspartate's metabolic plasticity enables carbon-nitrogen resource budgeting, leading to division of labor in yeast colonies.

The E3 ubiquitin ligase Pib1 regulates effective gluconeogenic shutdown in S. cerevisiae.

This study identifies Pib1 as an E3 ubiquitin ligase that mediates glucose repression in S. cerevisiae by promoting the degradation of the gluconeogenic transcription factor Rds2.

Metabolic constraints drive self-organization of specialized cell groups

The paper shows that metabolic constraints drive the self-organization of specialized cell groups in a clonal yeast colony under low glucose conditions.

A tRNA modification balances carbon and nitrogen metabolism by regulating phosphate homeostasis, to couple metabolism to cell cycle progression.

The paper shows tRNA U34-thiolation regulates phosphate homeostasis, linking carbon and nitrogen metabolism to cell cycle progression by controlling metabolic flux and phosphate availability.