Pancreatic islet cell stress induced by insulin-degrading enzyme deficiency promotes islet regeneration and protection from autoimmune diabetes
S. Zhu, E. Waeckel-Enee, A. Moser…·P. van Endert
This study shows that IDE deficiency in mice causes a low-level UPR, enhances beta cell proliferation, and protects against autoimmune diabetes through an anti-inflammatory pathway.