Initiation phase cellular reprogramming ameliorates DNA damage in the ERCC1 mouse model of premature aging.
P. T. Paine, C. Rechsteiner, F. Morandini, G. Desdin Mico, C. Mrabti, A. Parras, A. Haghani, R. Brooke, S. Horvath, A. Seluanov, V. Gorbunova, A. Ocampo
The paper uses partial cellular reprogramming to reduce DNA damage in an ERCC1 mouse model of premature aging, showing restoration of the epigenetic clock and DNA repair processes.
bioRxiv · May 12, 2023Cell Biology