Guardian crypt-base-goblet-cells protect the human colonic stem cell niche by triggering cholinergic calcium signal-dependent MUC2 secretion and luminal flushing
N. Pelaez-Llaneza, V. Jones, C. Kam, A. Lee, A. Parris, S. Tattan, M. Loader, J. Champion, G. Russam, B. Miller, N. Juge, R. Wharton, C. Speakman, S. Kapur, J. Hernon, , M. R. Williams
The paper identifies a mechanism by which cholinergic calcium signals in colonic stem cell niches trigger MUC2 secretion and luminal flushing.
bioRxiv · Jan 4, 2022 · PreprintCell Biology