A. Pal

On the synergy between myelin proteins P0, MBP, and P2 in peripheral nerve major dense line formation

This study investigates how myelin proteins P0, MBP, and P2 interact with lipid membranes and each other, revealing both synergistic and competitive effects on membrane structure and stability.

AP2/ERF transcription factors enriched in the drought-response transcriptome of the Thar desert tree Prosopis cineraria show higher copy number and greater DNA-binding affinity than orthologs in drought-sensitive species

This study identifies AP2/ERF transcription factors as key to drought tolerance in Prosopis cineraria, showing higher copy numbers and DNA-binding affinity compared to drought-sensitive species.

Influence of Incorporating Full-Fat Black Soldier Fly Larvae Meal (BSFLM) in Meat Type Chicken Diets on the Lower Gut Short Chain Fatty Acids profile, Gut Morphology and Intestinal Lesion Score

This study evaluates the effects of incorporating full-fat black soldier fly larvae meal into broiler chicken diets on gut health, short chain fatty acids, and intestinal morphology compared to diets with or without antibiotic growth promoters.

Physics-informed machine learning for automatic model reduction in chemical reaction networks

This paper introduces a physics-informed machine learning framework for automatic model reduction in chemical reaction networks, enhancing efficiency and accuracy in simulating complex systems like Aβ fibril aggregation.

A molecularly engineered lectin destroys EGFR and inhibits the growth of non-small cell lung cancer

This paper demonstrates that the engineered lectin H84T binds to and inhibits NSCLC cell growth by lysosomal degradation of EGFR, independent of EGFR mutation status.

Small molecule modulation of a redox-sensitive stress granule protein dissolves stress granules with beneficial outcomes for familial amyotrophic lateral sclerosis models

The paper identifies lipoamide as a small molecule that dissolves stress granules and improves outcomes in ALS models by modulating redox-sensitive proteins.

3-epicaryoptin induces G2/M phase cell cycle arrest and apoptosis in human breast cancer cells by disrupting the microtubule network, an in vitro and in silico investigation

This study investigates 3-epicaryoptin's anti-cancer effects on MCF-7 cells, showing it induces G2/M arrest and apoptosis by disrupting microtubules.

Metallo-protease Peptidase M84 from Bacillus altitudinis induces ROS dependent apoptosis in ovarian cancer cells by targeting PAR-1

This paper identifies Peptidase M84 from Bacillus altitudinis as an apoptosis inducer in ovarian cancer cells via PAR-1 mediated oxidative stress, showing anti-tumor effects in vitro and in vivo.

Upstream regulator of genomic imprinting in rice endosperm is a small RNA-associated chromatin remodeler

This study identifies OsCLSY3 as an essential chromatin remodeler for rice endosperm development and imprinting, regulated by RNA-directed DNA methylation and critical for small RNA production and imprinted gene expression.

Development of Gemcitabine-Modified miRNA Mimics as Cancer Therapeutics for Pancreatic Ductal Adenocarcinoma

Yuen and Hwang et al. developed Gem-modified miRNA mimics that show enhanced efficacy in inhibiting PDAC cell growth and tumor progression with reduced toxicity.

Bird Species diversity from the Southern West part of West Bengal, India

The paper estimates bird diversity in Southwest West Bengal, India, identifying 343 species and 55 new records using point count methods and citizen science.

Wound induced small-peptide mediated signalling cascade regulated by OsPSKR, dictates balance between growth and defense in rice

The paper identifies a peptide-mediated signaling cascade in rice regulated by OsPSKR that balances growth and defense responses during wounding.

Selection on many loci drove the origin and spread of a key innovation

The paper investigates the genetic basis of a key innovation in Littorina snails, finding polygenic selection and gradual evolution of live-bearing traits.

Effect of Lantana camara ethanolic leaf extract on survival and migration of MDA-MB-231 triple negative breast cancer cell line

This study shows that Lantana camara leaf extract inhibits MDA-MB-231 breast cancer cell survival and migration through apoptosis and cell cycle arrest.

SERS nanowire chip and machine learning enabled instant identification and classification of clinically relevant wild-type and antibiotic resistant bacteria at species and strain level

This paper develops a SERS chip combined with machine learning to rapidly identify and classify bacteria at species and strain levels, including antibiotic-resistant strains.

UFMTrack: Under-Flow Migration Tracker enabling analysis of the entire multi-step immune cell extravasation cascade across the blood-brain barrier in microfluidic devices

UFMTrack automates analysis of immune cell extravasation across the BBB in microfluidic devices, achieving 90% track reconstruction efficiency and reducing experimenter bias.

Anti-Biofilm Potential of Nanonized Eugenol against Pseudomonas aeruginosa

This study develops eugenol nanoparticles (ENPs) that show enhanced anti-biofilm activity against Pseudomonas aeruginosa compared to bulk eugenol.

Emergent remote stress-focusing drive submucosal collagen fiber remodeling in intestinal anastomotic surgery

This study identifies remote stress-focusing regions in intestinal anastomoses using geometric analysis, FEM, and in-vivo experiments, showing collagen fiber re-orientation correlates with stress distribution.

C-4-Modified Isotetrones Prevent Biofilm Growth and Persister Cell Resuscitation in Mycobacterium smegmatis

This study identifies isotetrone derivatives that inhibit biofilm growth and persister cell formation in M. smegmatis and enhance ciprofloxacin's effectiveness against antibiotic-tolerant cells.

Cinemeducation improves early clinical exposure to Inborn Errors of Metabolism

This study evaluates the use of cinemeducation to improve student interest, satisfaction, and academic performance in learning about Inborn Errors of Metabolism.

The "LINC" in between Delta40p53-miRNA axis in the regulation of cellular homeostasis

This study investigates how Delta40p53 regulates the LINC00176-microRNA-mRNA axis, affecting cellular processes and homeostasis independently of full-length p53.

Guardian crypt-base-goblet-cells protect the human colonic stem cell niche by triggering cholinergic calcium signal-dependent MUC2 secretion and luminal flushing

The paper identifies a mechanism by which cholinergic calcium signals in colonic stem cell niches trigger MUC2 secretion and luminal flushing.

Macrophage cell lines and murine infection by Salmonella Typhi L-form bacteria

This study shows that antibiotic treatment of Salmonella Typhi can generate L-form bacteria that infect macrophages and mice, suggesting a mechanism for antibiotic resistance and disease transmission.

Stably Accelerating Stiff Quantitative Systems Pharmacology Models: Continuous-Time Echo State Networks as Implicit Machine Learning

This paper introduces continuous-time echo state networks (CTESNs) to accelerate stiff quantitative systems pharmacology models, achieving up to 56x speedup with <5% error.

Network rewiring promotes cooperation in an aspirational learning model

The paper shows that network rewiring and a low-information learning model can sustain cooperation in a public goods game across a wide range of learning efficiencies.

Deciphering colchicine like actions of clerodin in terms of microtubule destabilization based mitotic abnormalities, G2/M-phase arrest, and plant polyploidy

This study shows clerodin induces mitotic abnormalities, G2/M arrest, and polyploidy in cells, similar to colchicine, through microtubule destabilization and shared binding site interaction.

Better expression profile of CD8 and CD4 gene in uterus of pregnant ewe in comparison to non-pregnant - a novel report

The paper reports higher CD8 and CD4 gene expression in the uterus of pregnant ewes compared to non-pregnant ewes, suggesting their potential as markers for pregnancy detection in sheep.

Resolvin E1 derived from eicosapentaenoic acid prevents hyperinsulinemia and hyperglycemia in a host genetic manner

This study shows EPA prevents hyperinsulinemia and hyperglycemia via RvE1, which acts through ERV1/ChemR23, and highlights host genetic variation in metabolic responses.

Mitochondrial Complex II In Intestinal Epithelial Cells Regulates T-cell Mediated Immunopathology

This study identifies mitochondrial complex II disruption in intestinal epithelial cells as a key driver of T-cell mediated intestinal immunopathology across multiple disease models.

Structural adaptation of oxygen tolerance in 4-hydroxybutyrl-CoA dehydratase, a key enzyme of archaeal carbon fixation

The paper investigates how 4HBD, a key enzyme in archaeal carbon fixation, adapted structurally to become oxygen-tolerant, revealing evolutionary changes that enabled aerobic metabolism.