B. Miller

Taking identity-by-descent analysis into the wild: Estimating realized relatedness in free-ranging macaques

The paper estimates realized relatedness in free-ranging macaques using IBD analysis from low coverage whole genome data, revealing genetic variation within kin classes and cryptic relatives.

Efficient Generation of Human Pluripotent Stem Cells from Frozen Cord Tissue via Chemical Reprogramming

This study demonstrates an efficient chemical method to generate iPSCs from frozen umbilical cord tissue, highlighting its safety and potential for regenerative medicine.

Mimicking an in cellulo environment for enzyme-free paper-based nucleic acid tests at the point of care

This paper develops an enzyme-free nucleic acid test using hybridization chain reaction and paper-based filtration to detect sub pM DNA levels, mimicking in cellulo conditions for point-of-care diagnostics.

Pharmacokinetic considerations for optimizing inhaled spray-dried pyrazinoic acid formulations

This study develops and evaluates inhaled POA formulations to improve TB treatment by enhancing pulmonary exposure and efficacy against pncA-mutant Mtb.

Supramolecular fibrous hydrogel augmentation of uterosacral ligament suspension for treatment of pelvic organ prolapse

This paper introduces a hydrogel biomaterial to augment uterosacral ligament suspension in a rat model, showing improved mechanical performance compared to standard surgery.

Z-REX: Shepherding Reactive Electrophiles to Specific Proteins Expressed either Tissue-Specifically or Ubiquitously, and Recording the Resultant Functional Electrophile-Induced Redox Responses in Larval Fish

This paper adapts a redox targeting tool for use in zebrafish embryos to study protein-specific electrophile-induced redox responses.

17α-estradiol, a lifespan-extending compound, attenuates liver fibrosis by modulating collagen turnover rates in male mice

This study shows that 17-E2 reduces liver fibrosis in male mice by decreasing collagen synthesis and increasing collagen degradation.

Guardian crypt-base-goblet-cells protect the human colonic stem cell niche by triggering cholinergic calcium signal-dependent MUC2 secretion and luminal flushing

The paper identifies a mechanism by which cholinergic calcium signals in colonic stem cell niches trigger MUC2 secretion and luminal flushing.

Microbiota induces aging-related leaky gut and inflammation by dampening mucin barriers and butyrate-FFAR2/3 signaling

The paper shows that aged microbiota causes leaky gut and inflammation by reducing butyrate and FFAR2/3, which weakens mucin barriers.

Genomic diversity of bacteriophages infecting Rhodobacter capsulatus and their relatedness to its gene transfer agent RcGTA

This study characterizes 26 new bacteriophages infecting Rhodobacter capsulatus, revealing genomic diversity and relationships to RcGTA.

A systematic comparison of fibroblasts derived from postmortem human dura mater versus dermal epithelium for neurodegenerative disease modeling

This study compares fibroblasts from postmortem human dura mater and dermal epithelium, finding significant differences in morphology, growth, marker expression, and chromosomal abnormalities.

Guest-host supramolecular assembly of injectable hydrogel fibers for cell encapsulation

This paper develops an injectable fibrous hydrogel using supramolecular assembly of HA nanofibers, showing improved mechanical properties and cell viability for tissue engineering.

Cell lineage as a predictor of immune response in neuroblastoma

This study identifies cell lineage as a key determinant of immune response in neuroblastoma by analyzing transcriptional signatures from 498 tumors and showing that mesenchymal-like cells are more immunogenic than adrenergic neuron-like cells.

Discovery of several thousand highly diverse circular DNA viruses

The paper identifies and characterizes thousands of new circular DNA viruses from animal samples using a bioinformatics pipeline and artificial neural networks.

Tumor regression mediated by oncogene withdrawal or erlotinib stimulates infiltration ofinflammatory immune cells in EGFR mutant lung tumors

The paper shows that erlotinib and oncogene withdrawal in EGFR mutant lung tumors increase infiltration of inflammatory immune cells, suggesting immunostimulatory effects of tumor regression.