TCR/CD3-based synthetic antigen receptors (TCC) convey superior antigen sensitivity combined with high fidelity of activation
T. Peters, V. Muehlgrabner, R. M. H. Velasco Cardenas, R. Platzer, J. Gohring, B. Salzer, A. Plach, M. Hoehrhan, I. Doel-Perez, V. D. R. Goncalves, J. S. Farfan, M. Lehner, H. Stockinger, W. W. Schamel, K. Schober, , J. B. Huppa
This study shows TCR/CD3-based synthetic antigen receptors (TCC) have superior antigen sensitivity and activation fidelity compared to second-generation CARs.
bioRxiv · Mar 16, 2023 · PreprintImmunology