Author

R. Platzer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Immunology· 3

Signature Assays, Organisms & Methods

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Approach:microscopy & imaging analysis· 4 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Assay:fluorescence / live-cell microscopy· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

J. B. Huppa· 7 shared H. Stockinger· 5 shared E. Sevcsik· 4 shared G. J. Schuetz· 4 shared J. Hellmeier· 3 shared M. Brameshuber· 3 shared E. Kurz· 2 shared I. Doel-Perez· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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7 shared papersBiophysics

J. B. Huppa

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Author profile →

7 papers

Recent·Most cited

TCR/CD3-based synthetic antigen receptors (TCC) convey superior antigen sensitivity combined with high fidelity of activation

T. Peters, V. Muehlgrabner, R. M. H. Velasco Cardenas, R. Platzer, J. Gohring, B. Salzer, A. Plach, M. Hoehrhan, I. Doel-Perez, V. D. R. Goncalves, J. S. Farfan, M. Lehner, H. Stockinger, W. W. Schamel, K. Schober, , J. B. Huppa

This study shows TCR/CD3-based synthetic antigen receptors (TCC) have superior antigen sensitivity and activation fidelity compared to second-generation CARs.

bioRxiv · Mar 16, 2023 · PreprintImmunology

Monomeric agonist peptide/MHCII complexes activate T-cells in an autonomous fashion

R. Platzer, J. Hellmeier, J. Gohring, I. Doel-Perez, P. Schatzlmaier, C. Bodner, G. J. Schuetz, E. Sevcsik, H. Stockinger, M. Brameshuber, J. B. Huppa

The paper uses live cell microscopy to show that monomeric agonist pMHCIIs can activate T-cells autonomously without requiring synaptic engagement or bystander pMHCIIs.

bioRxiv · Mar 13, 2023Immunology

Strategies for the site-specific decoration of DNA origami nanostructures with functionally intact proteins

J. Hellmeier, R. Platzer, V. Muehlgrabner, M. C. Schneider, E. Kurz, G. J. Schuetz, J. B. Huppa, E. Sevcsik

This study evaluates strategies for site-specific decoration of DNA origami with functional proteins, finding that PNA-based conjugation best preserves protein function and stoichiometry.

bioRxiv · Jul 1, 2021Biophysics

Temporal Analysis of T-Cell Receptor-Imposed Forces via Quantitative Single Molecule FRET Measurements

J. Göhring, F. Kellner, L. Schrangl, R. Platzer, E. Klotzsch, H. Stockinger, J. B. Huppa, G. Schuetz

The paper measures T-cell receptor forces using single molecule FRET, finding a 5 pN force peak during T-cell activation on gel-phase SLBs.

Nature Communications · May 4, 2021Peer-reviewedBiophysics

DNA origami demonstrate the unique stimulatory power of single pMHCs as T-cell antigens

J. Hellmeier, R. Platzer, A. S. Eklund, T. Schlichthaerle, A. Karner, V. Motsch, E. Kurz, V. Bamieh, M. Brameshuber, J. Preiner, R. Jungmann, H. Stockinger, G. J. Schuetz, J. B. Huppa, E. Sevcsik

The paper demonstrates that single pMHCs can robustly stimulate T-cells as isolated entities, identifying the minimal requirements for effective TCR-triggering.

Proceedings of the National Academy of Sciences · Jan 19, 2021Peer-reviewedBiophysics

The SPPL3-defined glycosphingolipid repertoire regulates immune responses by improving HLA class I access

M. L. M. Jongsma, M. Raaben, A. A. de Waard, T. Zhang, B. Cabukusta, R. Platzer, V. A. Blomen, A. Xagara, T. Verkerk, S. Bliss, L. Janssen, E. Stickel, S. Holst, R. Plomp, A. Mulder, , R. M. Spaapen

The paper identifies a glycosphingolipid (GSL) signature that inhibits HLA-I antigen presentation and shows its reversal by clinically approved drugs.

bioRxiv · Sep 26, 2020Immunology

Unscrambling Fluorophore Blinking for Comprehensive Cluster Detection via Photoactivated Localization Microscopy

R. Platzer, B. K. Rossboth, M. C. Schneider, E. Sevcsik, F. Baumgart, H. Stockinger, G. J. Schuetz, J. B. Huppa, M. Brameshuber

The paper develops a method to quantify and correct for fluorophore blinking in PALM to improve cluster detection accuracy.

bioRxiv · May 30, 2020Biophysics