Author

K. Schober

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Bioengineering· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1

Frequent Co-Authors

D. H. Busch· 4 shared M. Effenberger· 3 shared C. Stemberger· 2 shared C. Tschulik· 2 shared L. Germeroth· 2 shared M. P. Poltorak· 2 shared S. P. Fraessle· 2 shared V. Cletiu· 2 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersImmunology

D. H. Busch

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

DNA methylation profiling identifies TBKBP1 as potent amplifier of cytotoxic activity in CMV-specific human CD8+ T cells

Z. Yu, V. Sasidharan-Nair, A. Bonifacius, F. Khan, T. Buchta, M. Beckstette, J. Niemz, P. Hilgendorf, B. Pietzsch, P. Mausberg, A. Keller, C. S. Falk, D. S. Busch, M. Brinkmann, K. Schober, , J. Huehn

The paper identifies TBKBP1 as a key gene whose demethylation enhances cytotoxic activity in CMV-specific CD8+ T cells, suggesting it as a therapeutic target.

bioRxiv · Nov 6, 2023Immunology

Miniaturized CAR knocked onto CD3epsilon extends TCR function with CAR specificity under control of endogenous TCR signaling cascade

K. Manske, L. Dressler, S. P. Fraessle, M. Effenberger, C. Tschulik, V. Cletiu, E. Benke, M. Wagner, K. Schober, T. R. Mueller, D. H. Busch, C. Stemberger, L. Germeroth, M. P. Poltorak

This paper describes a method to miniaturize CAR T cells by integrating only the antigen-binding domain under the control of the endogenous TCR signaling cascade, preserving TCR function while enabling CAR specificity.

bioRxiv · May 30, 2023Bioengineering

TCR/CD3-based synthetic antigen receptors (TCC) convey superior antigen sensitivity combined with high fidelity of activation

T. Peters, V. Muehlgrabner, R. M. H. Velasco Cardenas, R. Platzer, J. Gohring, B. Salzer, A. Plach, M. Hoehrhan, I. Doel-Perez, V. D. R. Goncalves, J. S. Farfan, M. Lehner, H. Stockinger, W. W. Schamel, K. Schober, , J. B. Huppa

This study shows TCR/CD3-based synthetic antigen receptors (TCC) have superior antigen sensitivity and activation fidelity compared to second-generation CARs.

bioRxiv · Mar 16, 2023 · PreprintImmunology

Activation-inducible CAR expression enables precise control over engineered CAR T cell function

S. P. Fraessle, C. Tschulik, M. Effenberger, V. Cletiu, M. Gerget, K. Schober, D. H. Busch, L. Germeroth, C. Stemberger, M. P. Poltorak

This paper presents activation-inducible CAR T cells using CRISPR-mediated integration, enabling controlled CAR expression based on T cell activation status.

bioRxiv · Nov 8, 2022 · PreprintImmunology

Systematic identification of cancer-specific MHC-binding peptides with RAVEN

M. C. Baldauf, J. S. Gerke, A. Kirschner, F. Blaeschke, M. Effenberger, K. Schober, R. Alba Rubio, T. Kanaseki, M. M. Kiran, M. Dallmayer, J. Musa, N. Akpolat, A. N. Akatli, F. C. Rosman, O. Ozen, , T. G. Grunewald

The paper introduces RAVEN, a software tool that identifies cancer-specific genes encoding MHC-affine peptides from gene expression data, validated across 50 cancer types.

bioRxiv · Sep 24, 2017Immunology