Author

A. Platt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 4

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:gene regulatory network inference· 1 Research Focus:polygenic risk· 1 Research Focus:variant calling· 1 Research Focus:variant effect prediction· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

R. Patel· 2 shared S. Kumar· 2 shared A. Lutto· 1 shared A. P. Crupi· 1 shared A. Pivirotto· 1 shared B. S. Gilksberg· 1 shared C. C. Weber· 1 shared C. Carpenter· 1 shared

Activity by Year

2017-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersEvolutionary Biology

R. Patel

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Author profile →

4 papers

Recent·Most cited

Analyses of allele age and impact reveal human beneficial alleles are older than neutral controls

A. Pivirotto, A. Platt, R. Patel, S. Kumar, J. Hey

The paper estimates the ages of beneficial and deleterious alleles in humans and finds beneficial alleles are older than neutral controls, suggesting balancing selection rather than directional selection.

bioRxiv · Oct 9, 2023 · PreprintEvolutionary Biology

Genetic architecture and evolution of color variation in American black bears

E. E. Puckett, I. S. Davis, D. C. Harper, K. Wakamatsu, G. Battu, J. L. Belant, D. E. Beyer, C. Carpenter, A. P. Crupi, M. Davidson, C. S. DePerno, N. Forman, N. L. Fowler, D. L. Garshelis, N. Gould, , G. Barsh

This study identifies a missense mutation in TYRP1 responsible for the cinnamon color morph in American black bears and traces its evolutionary origin and spread.

bioRxiv · Aug 12, 2022Evolutionary Biology

Adaptive landscape of protein variation in human exomes

R. Patel, M. D. Sanderford, T. R. Lanham, K. Tamura, A. Platt, B. S. Gilksberg, J. T. Dudley, L. B. Scheinfeldt, K. Xu, S. Kumar

The paper develops an Evolutionary Probability Approach (EPA) to identify candidate adaptive polymorphisms in human exomes, finding thousands of missense variants likely under beneficial selection.

bioRxiv · Mar 14, 2018Evolutionary Biology

Protein Evolution Depends On Multiple Distinct Population Size Parameters

A. Platt, C. C. Weber, D. A. Liberles

The paper reviews how different population size parameters influence protein evolution and emphasizes the need for clear definitions to improve models of protein evolution.

bioRxiv · May 30, 2017Evolutionary Biology