J. Hey

Oncogenic RAS-Pathway Activation Drives Oncofetal Reprogramming and Creates Therapeutic Vulnerabilities in Juvenile Myelomonocytic Leukemia

This study identifies oncofetal reprogramming in juvenile myelomonocytic leukemia, linking RAS-pathway activation to fetal gene expression and revealing CD52 as a therapeutic target.

Epigenetic deregulation of IFN and WNT pathways in AT2 cells impairs alveolar regeneration (in COPD)

This study identifies epigenetic changes in AT2 cells from COPD patients that disrupt IFN and WNT pathways, impairing lung regeneration.

Analyses of allele age and impact reveal human beneficial alleles are older than neutral controls

The paper estimates the ages of beneficial and deleterious alleles in humans and finds beneficial alleles are older than neutral controls, suggesting balancing selection rather than directional selection.

Altered enhancer-promoter interaction leads to MNX1 expression in pediatric acute myeloid leukemia with t(7;12)(q36;p13)

The paper shows MNX1 overexpression in t(7;12)(q36;p13) AML is due to enhancer hijacking, not oncofusion, and is common in pediatric cases.

Aberrant MNX1 Expression Associated with t(7;12)(q36;p13) Pediatric Acute Myeloid 1 Leukemia Induces the Disease Through Altering Histone Methylation

This study identifies MNX1 as a driver of t(7;12)(q36;p13) pediatric AML by altering histone methylation and shows that targeting MNX1 can prevent leukemia development.

High-resolution epigenetic profiling identifies novel regulators of COPD in human lung fibroblasts

This study identifies novel epigenetic and transcriptomic regulators of COPD in human lung fibroblasts across disease stages.

Diverse routes of Club cell evolution in lung adenocarcinoma

This study identifies Club cells as a major cell-of-origin for lung adenocarcinoma, revealing two evolutionary trajectories similar to lung regeneration and tumor-specific epigenetic changes.

Model-based Assessments of Differential Introgression and Linked Natural Selection During Divergence and Speciation

The paper develops a model-based method to assess differential introgression and linked natural selection during divergence and speciation using genomic data from multiple species.

Exact calculation of the joint allele frequency spectrum for isolation with migration models

This paper presents a Markov chain method for exact calculation of the joint allele frequency spectrum under isolation with migration models and applies it to Drosophila melanogaster data.