R. Patel

Ongoing genome doubling promotes evolvability and immune dysregulation in ovarian cancer

This study shows that ongoing whole-genome doubling in ovarian cancer promotes cell diversity and immune dysregulation through chromosomal instability and quiescent states.

Imaging the extracellular matrix in live tissues and organisms with a glycan-binding fluorophore

This paper introduces a fluorophore for imaging extracellular matrix in live tissues and organisms by binding to glycans, enabling nonperturbative and wash-free visualization.

DUAL ACTION ELECTROCHEMICAL BANDAGE OPERATED by a PROGRAMMABLE MULTIMODAL WEARABLE POTENTIOSTAT

This paper develops a programmable multimodal wearable potentiostat for generating reactive oxygen species to treat biofilm-infected wounds, showing broad-spectrum antimicrobial activity.

Evaluation of Treatment of Methicillin-Resistant Staphylococcus aureus Biofilms with Intermittent Electrochemically-Generated H2O2 or HOCl

This study evaluates the effectiveness of intermittent electrochemical generation of H2O2 and HOCl against MRSA biofilms, showing that HOCl treatment duration and sequencing significantly impact biofilm reduction.

HOCl-producing Electrochemical Bandage is Active in Murine Polymicrobial Wound Infection

This study evaluates an HOCl-producing electrochemical bandage for treating polymicrobial wound infections in mice, showing significant bacterial load reduction without tissue toxicity.

Genotypic and phenotypic characterization of Enterococcus faecalis isolates from periprosthetic joint infections

This study characterizes genotypic and phenotypic features of Enterococcus faecalis isolates from periprosthetic joint infections, revealing genetic and phenotypic heterogeneity.

Differential response to LSD1 inhibition in prostate cancer reveals a YAP1 vulnerability in the neuroendocrine subtype

This paper shows that LSD1 inhibition is effective against neuroendocrine prostate cancer (NEPC) and that combining it with YAP/TEAD inhibition enhances treatment efficacy.

Low-intensity pulsed ultrasound stimulation (LIPUS) modulates microglial activation following intracortical microelectrode implantation.

This study shows that LIPUS reduces microglial activation and improves tissue-microelectrode integration after intracortical implantation.

Analyses of allele age and impact reveal human beneficial alleles are older than neutral controls

The paper estimates the ages of beneficial and deleterious alleles in humans and finds beneficial alleles are older than neutral controls, suggesting balancing selection rather than directional selection.

HOCl-producing Electrochemical Bandages for Treating Pseudomonas aeruginosa-Infected Murine Wounds

This study evaluates an HOCl-producing electrochemical bandage for treating Pseudomonas aeruginosa-infected wounds, showing significant biofilm reduction without impairing wound healing.

Characterizing Subcortical Structural Heterogeneity in Autism

This study examines subcortical structural differences in autism using MRI data, finding localized shape variations rather than volumetric differences, with age-related patterns observed.

56Fe ion exposure increases the incidence of lung and brain tumors at a similar rate in male and female mice

This study shows that 56Fe ion exposure increases lung and brain tumor incidence similarly in male and female mice, with 56Fe ions causing faster tumor development than X-rays.

Single-cell and spatial multi-omics highlight effects of anti-integrin therapy across cellular compartments in ulcerative colitis

This study uses single-cell and spatial multi-omics to show VDZ affects mononuclear phagocyte subsets and highlights gene expression patterns in UC.

Cell dichotomous role of STING in pulmonary hypertension

This study investigates the role of STING in pulmonary hypertension, finding that STING overactivation contributes to disease while global deficiency protects against it, with distinct cellular roles in smooth muscle and myeloid cells.

Spatial regulation of the glycocalyx component Podocalyxin is a switch for pro-metastatic function

This study identifies PODXL as a decoy receptor for GAL3, revealing its role in promoting metastasis through integrin-based invasion and differential cortical targeting regulated by ubiquitination.

Spatial transcriptomic profiling of coronary endothelial cells in SARS-CoV-2 myocarditis

This study uses spatial transcriptomics to analyze SARS-CoV-2 infection in coronary endothelial and myocardial tissues from COVID-19 patients, finding unique pro-inflammatory profiles in capillaries but not larger vessels.

Myxococcus xanthus, a nonpathogenic bacterium, eliminates Cryptococcus neoformans, a fungal pathogen of human, independent of cell-cell contact

This study shows that the nonpathogenic bacterium Myxococcus xanthus eliminates the fungal pathogen Cryptococcus neoformans without requiring cell-cell contact, by increasing fungal cell permeability.

The small GTPase ARF3 controls metastasis and invasion modality by regulating N-cadherin levels.

This study identifies ARF3 as a regulator of invasion modality and metastasis in prostate cancer by controlling N-cadherin levels.

Lin28b specifies an innate-like lineage of CD8+ T cells in early life

The paper shows Lin28b programs neonatal CD8+ T cells to have innate defense capabilities through transcriptional and epigenetic changes.

Unambiguous detection of SARS-CoV-2 subgenomic mRNAs with single cell RNA sequencing

This study evaluates scRNA-Seq methods for detecting SARS-CoV-2 subgenomic mRNAs, finding that 10X 5' with extended R1 sequencing best captures these viral RNAs at single-cell resolution.

Contribution of Uremia to Ureaplasma-Induced Hyperammonemia

The paper investigates how uremia enhances ammonia production by Ureaplasma species, contributing to hyperammonemia in lung transplant recipients.

Calorie Restriction in combination with GABA: improved glycaemic control in type 2 diabetes mouse model

This study shows that combining calorie restriction with GABA improves glycemic control and beta-cell regeneration in a T2D mouse model.

Repurposing statin and L-glutamine: replenishing β-cells in hyperlipidemic T2D mouse model

This study investigates the combined effect of pitavastatin and L-glutamine on glycemic control and β-cell regeneration in a T2D mouse model, finding improved insulin resistance and β-cell regeneration.

Lipid droplets modulate proteostasis, SQST-1/SQSTM1 dynamics, and lifespan in C. elegans

This study identifies lipid droplets as a proteostatic mediator in C. elegans that reduces protein ubiquitination, facilitates autophagy, and extends lifespan.

THEM6-mediated lipid remodelling sustains stress resistance in cancer

This study identifies THEM6 as a marker of ADT resistance in prostate cancer, showing its role in lipid homeostasis and stress response, and highlights it as a potential therapeutic target.

Cyclocreatine suppresses prostate tumorigenesis through dual effects on SAM and creatine metabolism

This study identifies cyclocreatine as a dual-action inhibitor of prostate cancer by blocking the phosphagen system and increasing S-adenosyl methionine levels.

mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants

This study examines antibody and memory B cell responses to mRNA vaccines against SARS-CoV-2 and assesses their effectiveness against emerging variants.

Evolution of Antibody Immunity to SARS-CoV-2

This study examines the evolution of antibody immunity to SARS-CoV-2 over time, finding that memory B cells evolve with increased potency and resistance to mutations.

Spatial enrichment of phosphoinositide metabolism is a molecular switch to promote metastasis.

This study identifies IQSEC1 variants that spatially regulate phosphoinositide metabolism to switch cell behavior from growth to invasion, with implications for metastasis.

Subtype Heterogeneity and Epigenetic Convergence in Neuroendocrine Prostate Cancer

This study identifies two distinct subtypes of neuroendocrine prostate cancer based on neuronal transcription factors and highlights their epigenetic convergence and therapeutic implications.