S. Kumar

Quantitative evaluation of LED based optical autofocus module

The paper evaluates an LED-based optical autofocus module using 2D autocorrelation analysis and demonstrates its axial stability over time.

FUSION: A web-based application for in-depth exploration of multi-omics data with brightfield histology

FUSION is a web-based tool that integrates spatial -omics data with histology to analyze tissue states and identify spatial linkages between molecular and histopathologic features.

Native mass spectrometry of membrane protein-lipid interactions in different detergent environments

This study uses native mass spectrometry to investigate how different detergents and charge-reducing molecules affect protein-lipid interactions in membrane proteins.

Chromosome-level genome assembly of autotetraploid Selenicereus megalanthus and gaining genomic insights into the evolution of trait patterning in diploid and polyploid pitaya species

De Novo Design of Integrin α5β1 Modulating Proteins for Regenerative Medicine

The paper designs de novo proteins called NeoNectins that specifically bind integrin α5β1, enhancing cell attachment and tissue integration in biomaterials.

Reversible kink instability drives ultrafast jumping in nematodes and soft robots

This paper demonstrates that a reversible kink instability in nematodes enhances jumping performance and proposes a bio-inspired model for soft robots.

Preclinical study of the human recombinant Erythropoietin (GBPD002) compared with Eprex

This study compares the safety and toxicity of GBPD002 and Eprex(R), two recombinant human erythropoietins, in rats, finding similar toxicological profiles and no significant differences.

Elucidating key determinants of engineered scFv antibody in MMP-9 binding using high throughput screening and machine learning

The paper uses high-throughput screening and machine learning to identify key determinants of scFv antibody binding to MMP-9.

The role of Tyr34 in proton-coupled electron transfer of human manganese superoxide dismutase

This study investigates the role of Tyr34 in MnSOD catalysis using neutron diffraction, X-ray spectroscopy, and quantum chemistry calculations, revealing its impact on proton-coupled electron transfer.

In Vivo Simvastatin and Brain Radiation in a Model of HER2+ Inflammatory Breast Cancer Brain Metastasis

This study examines if simvastatin and whole-brain radiation affect HER2+ inflammatory breast cancer brain metastases in a mouse model, finding mixed effects on micrometastases but not macrometastases.

A Rigorous Multi-Laboratory Study of Known PDAC Biomarkers Identifies Increased Sensitivity and Specificity Over CA19-9 Alone

This study evaluates combinations of PDAC biomarkers across multiple labs, finding improved sensitivity and specificity for early-stage detection compared to CA19-9 alone.

Imaging of MAP kinase dynamics reveals endocytic regulation of pulsatile signalling and network re-wiring in response to targeted therapy in EGFR-mutant non-small cell lung cancer

The paper uses single-cell imaging to show that drug-tolerant cells in EGFR-mutant lung cancer rewired ERK signaling through endocytic pathways and adhesion complexes, driven by YAP and PTPRS.

Origins and diversity of pan-isotype human bone marrow plasma cells

The paper investigates the origins and diversity of human bone marrow plasma cells, identifying distinct functional profiles and sources of IgE-producing cells in peanut allergy.

Digital Profiling of Tumor Extracellular Vesicle-associated RNAs Directly from Unprocessed Blood Plasma

EV-CLIP detects tumor-derived extracellular vesicle RNAs directly from blood plasma with high sensitivity, enabling precise monitoring of cancer mutations and EV subpopulations.

Dissecting neurofilament tail sequence-phosphorylation-structure relationships with multicomponent reconstituted protein brushes

The paper investigates how neurofilament tail sequence and phosphorylation affect protein brush conformation using reconstituted brushes and theoretical models.

Probing the Molecular Interactions of A22 with Prokaryotic Actin MreB and Eukaryotic Actin: A Computational and Experimental Study

This study investigates A22's interactions with prokaryotic MreB and eukaryotic actin using computational and experimental methods, revealing strong binding and toxicity to eukaryotic cells.

Discovering Fragile Clades And Causal Sequences In Phylogenomics By Evolutionary Sparse Learning

The paper introduces metrics to identify fragile clades and causal sequences in phylogenomics using evolutionary sparse learning, validated across fungi, plant, and animal datasets.

TRPV4 modulation affects mitochondrial parameters in adipocytes and its inhibition upregulates lipid accumulation

This study shows TRPV4 inhibition increases lipid accumulation in adipocytes by altering mitochondrial parameters and lipid-droplet formation.

Viscoelastic high-molecular-weight hyaluronic acid hydrogels support rapid glioblastoma cell invasion with leader-follower dynamics

This study shows that high-molecular-weight hyaluronic acid hydrogels promote faster glioblastoma cell invasion with leader-follower dynamics compared to low-molecular-weight HA hydrogels.

CITE-seq analysis reveals human cytomegalovirus and diabetes-associated adaptive NK cell alterations in cardiovascular disease.

The paper uses CITE-seq to analyze NK cell alterations in CAD patients, finding SPON2/IFNG ratio and adaptive NK cell signatures correlate with disease severity and inflammation.

Nuclear compression-mediated DNA damage drives ATR-dependent Lamin expression and mouse ESC differentiation

The paper shows that nuclear compression-induced DNA damage drives mESC differentiation via ATR-dependent Lamin A/C regulation.

Pyruvate Kinase M2 regulates Japanese encephalitis virus replication by interacting with NS1 protein

This study shows PKM2 reduces JEV replication by interacting with NS1, highlighting a new role for PKM2 in viral neuropathogenesis.

Transcriptomic characterization of recombinant Clostridium beijerinckii NCIMB 8052 expressing methylglyoxal synthase and glyoxal reductase from Clostridium pasteurianum ATCC 6013

This study uses RNA sequencing to analyze the transcriptome of a genetically modified Clostridium beijerinckii strain, revealing gene expression changes associated with enhanced butanol production from lactose.

Unravelling the roadblocks to 1,2-propanediol biosynthesis in select solventogenic Clostridium species

This study investigates the challenges in producing 1,2-propanediol using solventogenic Clostridium species, finding that recombinant strains fail to convert intermediates efficiently and that regulatory mechanisms may limit methylglyoxal pathway activity.

UBA1-CDK16: A Sex-Specific Chimeric RNA and Its Role in Immune Sexual Dimorphism

The paper identifies a female-specific chimeric RNA, UBA1-CDK16, and shows its role in myeloid differentiation and immune sexual dimorphism.

A proteome-wide quantitative platform for nanoscale spatially resolved extraction of membrane proteins into native nanodiscs

This paper introduces a platform for high-throughput extraction of membrane proteins into native nanodiscs while preserving their local membrane context and provides a database for optimized extraction conditions.

Microenvironment shapes small-cell lung cancer neuroendocrine states and presents therapeutic opportunities

This study maps the SCLC tumor microenvironment and identifies cancer-associated fibroblasts as key drivers of neuroendocrine state plasticity and poor prognosis.

XBB.1.5 monovalent booster improves antibody binding and neutralization against emerging SARS-CoV-2 Omicron variants

The paper evaluates the effectiveness of an XBB.1.5 monovalent booster vaccine, showing improved antibody binding and neutralization against SARS-CoV-2 Omicron variants.

Stress relaxing granular bioprinting materials enable complex and uniform organoid self-organization

This paper introduces a tunable granular biomaterial, MAGIC matrix, that enables precise control of initial conditions for tissue growth, leading to improved organoid reproducibility and complexity.

Novel spirocyclic dimer, SpiD3, targets chronic lymphocytic leukemia survival pathways with potent preclinical effects

This paper evaluates SpiD3, a novel spirocyclic dimer, showing potent anti-leukemic effects in CLL cells, including resistance to ibrutinib, by targeting NF-κB signaling and the UPR.