Disruption of immunoglobulin heavy and light chain assembly by antisense oligonucleotides impairs protein homeostasis and myeloma cell survival
C. Horiot, M. Roussel, A. Praite, J. Pollet, S. Bender, C. Sirac, A. Bonaud, L. Delpy
This study shows that antisense oligonucleotides targeting IgG mRNA reduce IgG secretion in myeloma cells, leading to toxic free-light chain accumulation and cell death.
bioRxiv · Aug 29, 2023 · PreprintImmunology