S. Bender

A mouse model of cardiac AL amyloidosis unveils mechanisms of tissue accumulation and toxicity of amyloid fibrils

This paper develops a mouse model of cardiac AL amyloidosis that reproduces human disease features, including amyloid deposits and cardiac dysfunction, and identifies a role for partial LC degradation in fibril formation.

Disruption of immunoglobulin heavy and light chain assembly by antisense oligonucleotides impairs protein homeostasis and myeloma cell survival

This study shows that antisense oligonucleotides targeting IgG mRNA reduce IgG secretion in myeloma cells, leading to toxic free-light chain accumulation and cell death.

Prospective Fecal Microbiomics Biomarkers for Chronic Wasting Disease

This study identifies fecal microbiome and metabolomics biomarkers that can differentiate CWD-positive from CWD-negative deer with 70% accuracy.

A dual function for the chromatin organizer Special A-T rich Binding Protein 1 in B-lineage cells

This study investigates SATB1's role in B-lineage cells, finding it is not essential for B cell development but acts as both a positive and negative regulator of Ig gene transcription in naive and activated B cells, respectively.

The IgH Eμ-MAR regions promote UNG-dependent error-prone repair to optimize somatic hypermutation

The paper shows that IgH Eμ-MAR regions limit error-prone repair to the variable region of Ig genes by promoting UNG-dependent repair, affecting somatic hypermutation patterns.

New models to study plasma cells in mouse based on the restriction of IgJ expression to antibody secreting cells.

The paper introduces two new mouse models, IgJGFP and IgJCreERT2, for studying plasma cells by leveraging IgJ expression as a marker for antibody-secreting cells.

Multiplexed single-cell profiling of post-perturbation transcriptional responses to define cancer vulnerabilities and therapeutic mechanism of action

The paper introduces MIX-Seq, a method for multiplexed single-cell transcriptional profiling of cancer cell responses to perturbations, revealing drug mechanisms and predicting cell viability.

Full-length immunoglobulin high-throughput sequencing reveals specific novel mutational patterns in POEMS syndrome

This study uses high-throughput Ig repertoire sequencing to identify specific mutational patterns in POEMS syndrome, aiding in diagnosis and detection of low-abundance plasma cell clones.

Glomerulosclerosis and kidney failure in a mouse model of monoclonal immunoglobulin light-chain deposition disease

This study develops a mouse model of light chain deposition disease, showing that pathogenic light chains cause glomerulosclerosis and kidney failure, and identifies potential therapeutic targets.