Author

J. Pollet

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 7 Biochemistry· 1 Cancer Biology· 1 Microbiology· 1 Pathology· 1

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Approach:experimental assay· 11 Research Focus:cell type annotation· 6 Organism:mouse· 6 Organism:human· 5 Assay:proteomics· 5 Research Focus:cell signaling & trafficking· 3 Research Focus:chromatin & epigenetic regulation· 3 Research Focus:host-pathogen & immune response· 3

Frequent Co-Authors

M. E. Bottazzi· 4 shared P. J. Hotez· 4 shared C. Poveda· 3 shared U. Strych· 3 shared W.-H. Chen· 3 shared A. C. de Araujo Leao· 2 shared B. Keegan· 2 shared B. Zhan· 2 shared

Activity by Year

2020-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersImmunology

M. E. Bottazzi

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11 papers

Recent·Most cited

Disruption of immunoglobulin heavy and light chain assembly by antisense oligonucleotides impairs protein homeostasis and myeloma cell survival

C. Horiot, M. Roussel, A. Praite, J. Pollet, S. Bender, C. Sirac, A. Bonaud, L. Delpy

This study shows that antisense oligonucleotides targeting IgG mRNA reduce IgG secretion in myeloma cells, leading to toxic free-light chain accumulation and cell death.

bioRxiv · Aug 29, 2023 · PreprintImmunology

RNA-dependent RNA polymerase of predominant human norovirus forms liquid-liquid phase condensates as viral replication factories

S. Kaundal, A. Ramakrishnan, B. V. Ayyar, S. Shanker, G. Kaur, S. E. Crawford, J. Pollet, F. Stossi, M. K. Estes, B. V. V. Prasad

bioRxiv · Aug 24, 2023 · PreprintBiochemistry

Core enhancers of the 3'RR optimize IgH nuclear position and loop conformation for oriented CSR

C. Bruzeau, J. Pollet, M. Thomas, Z. Ba, D. Roulois, E. PINAUD, S. Le Noir

The paper shows that core enhancers of the IgH 3RR preorganize B cell nuclei to facilitate class switch recombination by controlling nuclear positioning and loop formation.

bioRxiv · Jul 11, 2023 · PreprintImmunology

The impact of vaccine-linked chemotherapy on liver health in a mouse model of chronic Trypanosoma cruzi infection

K. Jones, D. M. Nguyen, C. Poveda, J. Pollet, F. Gusovsky, M. E. Bottazzi, P. J. Hotez

This study evaluates the impact of vaccine-linked chemotherapy on liver health in a mouse model of chronic Trypanosoma cruzi infection, finding that the treatment better preserves liver health compared to curative doses of benznidazole.

bioRxiv · Jul 11, 2023Pathology

Infection of equine bronchial epithelial cells with a SARS-CoV-2 pseudovirus

R. M. Legere, A. R. Allegro, Y. Affram, B. Petri da Silveira, J. L. Fridley, K. M. Wells, N. Oezguen, R. C. Burghardt, G. A. Wright, J. Pollet, A. I. Bordin, P. de Figueiredo, J. L. Leibowitz, N. D. Cohen

This study shows equine bronchial epithelial cells can be infected by a SARS-CoV-2 pseudovirus, but with lower efficiency than human cells, likely due to lower ACE2 expression.

bioRxiv · Jan 26, 2023 · PreprintMicrobiology

A dual function for the chromatin organizer Special A-T rich Binding Protein 1 in B-lineage cells

M. Thomas, O. Martin, C. Bruzeau, J. Pollet, S. Bender, C. Carrion, S. Le Noir, E. Pinaud

This study investigates SATB1's role in B-lineage cells, finding it is not essential for B cell development but acts as both a positive and negative regulator of Ig gene transcription in naive and activated B cells, respectively.

bioRxiv · Sep 6, 2022 · PreprintImmunology

CD95 expression in triple negative breast cancer blocks induction of an inflammatory state through differential regulation of NF-kB Signaling

J.-P. Guegan, J. Pollet, C. Ginestier, E. Charafe-Jauffret, M. E. Peter, P. Legembre

This study identifies CD95 interaction partners KPC2 and p65, showing CD95 loss in TNBCs promotes NF-κB activation and pro-inflammatory cytokine production.

bioRxiv · Apr 7, 2021 · PreprintCancer Biology

Genetic Modification to Design a Stable Yeast-expressed Recombinant SARS-CoV-2 Receptor Binding Domain as a COVID-19 Vaccine Candidate

W.-H. Chen, J. Wei, R. T. Kundu, R. Adhikari, Z. Liu, J. Lee, L. Versteeg, C. Poveda, B. Keegan, M. J. Villar, A. C. de Araujo Leao, J. Altieri Rivera, P. M. Gillespie, J. Pollet, U. Strych, , M. E. Bottazzi

The paper genetically modifies SARS-CoV-2 RBD variants in yeast to identify a more stable and manufacturable vaccine candidate.

bioRxiv · Nov 9, 2020Immunology

SARS-CoV-2 RBD219-N1C1: A Yeast-Expressed SARS-CoV-2 Recombinant Receptor-Binding Domain Candidate Vaccine Stimulates Virus Neutralizing Antibodies and T-cell Immunity in Mice

J. Pollet, W.-H. Chen, L. Versteeg, B. Keegan, B. Zhan, J. Wei, Z. Liu, J. Lee, R. Kundu, R. Adhikari, C. Poveda, M. J. Villar Mondragon, A. C. de Araujo Leao, J. Altieri Rivera, Z. Momin, , M. E. Bottazzi

This study develops a yeast-expressed SARS-CoV-2 RBD protein vaccine candidate, RBD219-N1C1, which induces neutralizing antibodies and T-cell responses in mice.

bioRxiv · Nov 4, 2020Immunology

Splice switching oligonucleotide mediated gene knockdown in B cells and plasma cells

L. Delpy, A. Marchalot, J.-M. Lambert, F. Boyer, J. Pollet, J. Cook-Moreau, J. Feuillard, N. Faumont

This paper demonstrates the effectiveness of splice switching oligonucleotides in knocking down c-REL and RELA expression in B cells and plasma cells, with potential therapeutic applications in B-lineage cancers.

bioRxiv · Sep 18, 2020 · PreprintImmunology

Yeast-Expressed SARS-CoV Recombinant Receptor-Binding Domain (RBD219-N1) Formulated with Aluminum Hydroxide Induces Protective Immunity and Reduces Immune Enhancement

W.-H. Chen, X. Tao, A. Agrawal, A. Algaissi, B.-H. Peng, J. Pollet, U. Strych, M. E. Bottazzi, P. J. Hotez, S. Lustigman, L. Du, S. Jiang, C.-T. K. Tseng

This paper develops a SARS-CoV subunit vaccine using yeast-expressed RBD219-N1 with Alhydrogel® and shows it provides full protection against SARS-CoV challenge in mice.

bioRxiv · May 15, 2020Immunology